Magnetic Nanoparticles with High Specific Absorption Rate at Low Alternating Magnetic Field.

Nano LIFE · 2015 · Benefit · Insufficient evidence

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BenefitInsufficient evidencePaper 2968

The paper reports synthesis of gamma-FeO magnetic nanoparticles and measures their heating performance under an alternating magnetic field. Reported nanoparticle SAR values range from 22–200 W/g at AMF strengths of 100–500 Oe and frequency of 160 kHz, despite…

Study snapshot

PublicationNano LIFE · 2015
Study typeengineering
Reported directionBenefit
Evidence ratingInsufficient

Abstract

This paper describes the synthesis and properties of a new type of magnetic nanoparticle (MNP) for use in the hyperthermia treatment of tumors. These particles consist of 2-4 nm crystals of gamma-FeO gathered in 20-40 nm aggregates with a coating of carboxymethyl-dextran, producing a zetasize of 110-120 nm. Despite their very low saturation magnetization (1.5-6.5 emu/g), the specific absorption rate (SAR) of the nanoparticles is 22-200 W/g at applied alternating magnetic field (AMF) with strengths of 100-500 Oe at a frequency of 160 kHz.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeengineering
Effect directionbenefit
PopulationNot supplied
Sample sizeNot supplied
ExposureELF · 0.16 MHz
Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

The paper reports synthesis of gamma-FeO magnetic nanoparticles and measures their heating performance under an alternating magnetic field. Reported nanoparticle SAR values range from 22–200 W/g at AMF strengths of 100–500 Oe and frequency of 160 kHz, despite low saturation magnetization (1.5–6.5 emu/g).

Outcomes measured

  • Nanoparticle specific absorption rate (SAR) under alternating magnetic field
  • Nanoparticle physical/chemical properties (size, aggregation, coating, saturation magnetization)

Limitations

  • No biological/clinical outcomes reported in the abstract (focus is on material synthesis and SAR measurements).
  • No sample size or experimental replication details provided in the abstract.
  • Exposure duration and detailed AMF parameters beyond field strength and frequency are not described in the abstract.
View raw extracted JSON
{
  "study_type": "engineering",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": 0.16,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Nanoparticle specific absorption rate (SAR) under alternating magnetic field",
    "Nanoparticle physical/chemical properties (size, aggregation, coating, saturation magnetization)"
  ],
  "main_findings": "The paper reports synthesis of gamma-FeO magnetic nanoparticles and measures their heating performance under an alternating magnetic field. Reported nanoparticle SAR values range from 22–200 W/g at AMF strengths of 100–500 Oe and frequency of 160 kHz, despite low saturation magnetization (1.5–6.5 emu/g).",
  "effect_direction": "benefit",
  "limitations": [
    "No biological/clinical outcomes reported in the abstract (focus is on material synthesis and SAR measurements).",
    "No sample size or experimental replication details provided in the abstract.",
    "Exposure duration and detailed AMF parameters beyond field strength and frequency are not described in the abstract."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "magnetic nanoparticles",
    "hyperthermia",
    "tumor treatment",
    "specific absorption rate",
    "alternating magnetic field",
    "gamma-FeO",
    "carboxymethyl-dextran",
    "160 kHz"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1142/s1793984415500026
PubMed: 26884816

Read the original paper →

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