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Research on in vitro release of Isoniazid (INH) super paramagnetic microspheres in different magnetic fields.

Pakistan journal of pharmaceutical sciences · 2016 · Benefit · Low evidence

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BenefitLow evidencePaper 2875

In PBS at pH 7.4, the microspheres showed 8-hour sustained release under magnetic field and the release rate was accelerated. In PBS at pH 3, release was faster and was reported to complete fastest in 2 hours under an oscillating magnetic field; longer magnet…

Study snapshot

PublicationPakistan journal of pharmaceutical sciences · 2016
Study typein_vitro
Reported directionBenefit
Evidence ratingLow

Abstract

To explore in vitro release rules of isoniazid (INH) when Isoniazid Super paramagnetic Iron Oxide Microspheres (ISPIOM) are subject to no external magnetic field, applied mechanical magnetic field and scillating magnetic field. ISPIOM was prepared by using the spray drying method; Isoniazid contented in the microspheres was determined, the drug loading capacity and encapsulation efficiency were calculated. Release of isoniazid in the microspheres was determined respectively under the effect of no external magnetic field, applied mechanical magnetic field and oscillating magnetic field, to explore the release rules. In solution with pH=7.4 PBS, microspheres featured 8-hour sustained release under the effect of magnetic field, the released rate of the microspheres is accelerated,. In solution with pH=3 PBS, microspheres release faster and could realize the fastest completion of release in 2 hours under the effect of oscillating magnetic field. To join the external magnetic field in different point time to can't affect the release, under pH=3 of medium, ISPIOM release faster; under the effect of magnetic field, the released rate of the microspheres is accelerated, and the longer effect of magnetic field, the faster release. Oscillating magnetic field can make ISPIOM within a certain period of time, get ideal release curve, so as to achieve good control release effect.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionbenefit
PopulationNot supplied
Sample sizeNot supplied
ExposureNot supplied
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In PBS at pH 7.4, the microspheres showed 8-hour sustained release under magnetic field and the release rate was accelerated. In PBS at pH 3, release was faster and was reported to complete fastest in 2 hours under an oscillating magnetic field; longer magnetic-field exposure was associated with faster release.

Outcomes measured

  • In vitro isoniazid release rate/kinetics from superparamagnetic iron oxide microspheres
  • Sustained release duration (e.g., 8-hour sustained release at pH 7.4)
  • Time to completion of release (e.g., 2 hours at pH 3 under oscillating magnetic field)

Limitations

  • Magnetic field parameters (e.g., strength, frequency) not reported in the abstract
  • In vitro study; no in vivo/clinical outcomes reported
  • No sample size or replication details provided in the abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": null,
    "source": "external magnetic field (mechanical/oscillating)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "In vitro isoniazid release rate/kinetics from superparamagnetic iron oxide microspheres",
    "Sustained release duration (e.g., 8-hour sustained release at pH 7.4)",
    "Time to completion of release (e.g., 2 hours at pH 3 under oscillating magnetic field)"
  ],
  "main_findings": "In PBS at pH 7.4, the microspheres showed 8-hour sustained release under magnetic field and the release rate was accelerated. In PBS at pH 3, release was faster and was reported to complete fastest in 2 hours under an oscillating magnetic field; longer magnetic-field exposure was associated with faster release.",
  "effect_direction": "benefit",
  "limitations": [
    "Magnetic field parameters (e.g., strength, frequency) not reported in the abstract",
    "In vitro study; no in vivo/clinical outcomes reported",
    "No sample size or replication details provided in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "isoniazid",
    "superparamagnetic iron oxide microspheres",
    "in vitro release",
    "magnetic field",
    "oscillating magnetic field",
    "controlled release",
    "spray drying",
    "PBS pH 7.4",
    "PBS pH 3"
  ],
  "suggested_hubs": [
    {
      "slug": "other",
      "weight": 0.2,
      "reason": "Magnetic-field-assisted drug release in vitro; not directly related to environmental/telecom EMF exposure."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 28412681

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