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Effects of Long-Term Exposure to 60 GHz Millimeter-Wavelength Radiation on Genotoxicity & Heat Shock Protein Expression of Cells Derived from Human Eye

2016 · No effect · Low evidence

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No effectLow evidencePaper 2371

Human corneal epithelial and lens epithelial cells exposed to 60 GHz radiation for 24 h at 1 mW/cm² showed no statistically significant increase in micronucleus frequency versus sham-exposed and incubator controls. Comet assay results and heat shock protein e…

Study snapshot

Publicationmanual · 2016
Study typein_vitro
Reported directionNo effect
Evidence ratingLow

Abstract

Effects of Long-Term Exposure to 60 GHz Millimeter-Wavelength Radiation on Genotoxicity & Heat Shock Protein Expression of Cells Derived from Human Eye Koyama S, Narita E, Shimizu Y, Suzuki Y, Shiina T, Taki M, Shinohara N, Miyakoshi J.Effects of Long-Term Exposure to 60 GHz Millimeter-Wavelength Radiation on the Genotoxicity and Heat Shock Protein (Hsp) Expression of Cells Derived from Human Eye. Int J Environ Res Public Health. 2016 Aug 8;13(8). pii: E802. doi: 10.3390/ijerph13080802. Abstract Human corneal epithelial (HCE-T) and human lens epithelial (SRA01/04) cells derived from the human eye were exposed to 60 gigahertz (GHz) millimeter-wavelength radiation for 24 h. There was no statistically significant increase in the micronucleus (MN) frequency in cells exposed to 60 GHz millimeter-wavelength radiation at 1 mW/cm² compared with sham-exposed controls and incubator controls. The MN frequency of cells treated with bleomycin for 1 h provided positive controls. The comet assay, used to detect DNA strand breaks, and heat shock protein (Hsp) expression also showed no statistically significant effects of exposure. These results indicate that exposure to millimeter-wavelength radiation has no effect on genotoxicity in human eye cells. ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionno_effect
PopulationHuman corneal epithelial (HCE-T) and human lens epithelial (SRA01/04) cells
Sample sizeNot supplied
ExposuremmWave · 60000 MHz · 24 h
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Human corneal epithelial and lens epithelial cells exposed to 60 GHz radiation for 24 h at 1 mW/cm² showed no statistically significant increase in micronucleus frequency versus sham-exposed and incubator controls. Comet assay results and heat shock protein expression also showed no statistically significant effects; bleomycin treatment served as a positive control for MN frequency.

Outcomes measured

  • Micronucleus (MN) frequency
  • DNA strand breaks (comet assay)
  • Heat shock protein (Hsp) expression
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "mmWave",
    "source": null,
    "frequency_mhz": 60000,
    "sar_wkg": null,
    "duration": "24 h"
  },
  "population": "Human corneal epithelial (HCE-T) and human lens epithelial (SRA01/04) cells",
  "sample_size": null,
  "outcomes": [
    "Micronucleus (MN) frequency",
    "DNA strand breaks (comet assay)",
    "Heat shock protein (Hsp) expression"
  ],
  "main_findings": "Human corneal epithelial and lens epithelial cells exposed to 60 GHz radiation for 24 h at 1 mW/cm² showed no statistically significant increase in micronucleus frequency versus sham-exposed and incubator controls. Comet assay results and heat shock protein expression also showed no statistically significant effects; bleomycin treatment served as a positive control for MN frequency.",
  "effect_direction": "no_effect",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "60 GHz",
    "millimeter-wave",
    "mmWave",
    "human eye cells",
    "corneal epithelial cells",
    "lens epithelial cells",
    "genotoxicity",
    "micronucleus",
    "comet assay",
    "heat shock protein"
  ],
  "suggested_hubs": [
    {
      "slug": "5g-policy",
      "weight": 0.55,
      "reason": "Study examines 60 GHz millimeter-wave exposure, relevant to mmWave frequencies used in some 5G contexts."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/ijerph13080802
PubMed: Not supplied

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