Resveratrol may reverse effects of long-term occupational exposure to EMF on power plant workers

2017 · Mixed · Low evidence

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MixedLow evidencePaper 2234

Compared with the reference group, exposed workers had higher urinary 8-OHdG and F2-isoprostane, and lower plasma NF-κB and IL-6. Resveratrol supplementation (500 mg twice daily) significantly reversed adverse impacts attributed to ELF-EMF exposure, with stim…

Study snapshot

Publicationmanual · 2017

Study typerandomized_trial

Reported directionMixed

Evidence ratingLow

Abstract

Resveratrol may reverse effects of long-term occupational exposure to EMF on power plant workers Zhang D, Zhang Y, Zhu B, Zhang H, Sun Y, Sun C. Resveratrol may reverse the effects of long-term occupational exposure to electromagnetic fields on workers of a power plant. Oncotarget. 2017 May 7. doi: 10.18632/oncotarget.17668. Abstract High-voltage electricity lines are known to generate extremely low-frequency electromagnetic fields (ELF-EMFs). With the process of urbanization, increasing concerns has been focused on the potentially hazardous impacts of ELF-EMF on human health, and the conclusions are controversial. Little is known about the method of prevention against ELF-EMF induced healthy problems. A total of 186 male workers with occupational exposure to high-voltage electricity lines, and 154 male subjects with insignificant exposure as reference control were enrolled in this study. Resveratrol or placebo was given as dietary supplements (500 mg twice daily), and several inflammatory biomarkers and biomarkers of oxidative stress were assessed. Workers who had long-term exposure to high-voltage electricity lines exhibited elevated urinary levels of 8-hydroxy-2-deoxy-guanosine (8- OHdG) and F2-isoprostane, compared to the reference group. Lower plasma nuclear factor kappa B (NF-κB) and interleukin (IL)-6 were observed in exposed workers compared to the reference group. Resveratrol significantly reversed the adverse impacts of ELF-EMF. Stimulated cytokine production by resveratrol was found in exposed workers but not in the reference group. This study supported that occupational and long-term exposure to high- voltage electricity lines has an adverse effect on homeostasis of human body, and resveratrol supplement could be an effective protection strategy against the adverse effects induced by ELF-EMFs. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typerandomized_trial

Effect directionmixed

PopulationMale power plant workers with occupational exposure to high-voltage electricity lines; male reference controls with insignificant exposure

Sample size340

ExposureELF · long-term

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Urinary 8-hydroxy-2-deoxy-guanosine (8-OHdG)
Urinary F2-isoprostane
Plasma nuclear factor kappa B (NF-κB)
Plasma interleukin-6 (IL-6)
Cytokine production (stimulated by resveratrol)

Limitations

Specific ELF-EMF exposure metrics (e.g., field strength, frequency) not reported in abstract
Randomization/blinding procedures and allocation details not described in abstract
Duration of supplementation/follow-up not stated in abstract
Only male participants included

View raw extracted JSON

{
  "study_type": "randomized_trial",
  "exposure": {
    "band": "ELF",
    "source": "occupational",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "long-term"
  },
  "population": "Male power plant workers with occupational exposure to high-voltage electricity lines; male reference controls with insignificant exposure",
  "sample_size": 340,
  "outcomes": [
    "Urinary 8-hydroxy-2-deoxy-guanosine (8-OHdG)",
    "Urinary F2-isoprostane",
    "Plasma nuclear factor kappa B (NF-κB)",
    "Plasma interleukin-6 (IL-6)",
    "Cytokine production (stimulated by resveratrol)"
  ],
  "main_findings": "Compared with the reference group, exposed workers had higher urinary 8-OHdG and F2-isoprostane, and lower plasma NF-κB and IL-6. Resveratrol supplementation (500 mg twice daily) significantly reversed adverse impacts attributed to ELF-EMF exposure, with stimulated cytokine production observed in exposed workers but not in the reference group.",
  "effect_direction": "mixed",
  "limitations": [
    "Specific ELF-EMF exposure metrics (e.g., field strength, frequency) not reported in abstract",
    "Randomization/blinding procedures and allocation details not described in abstract",
    "Duration of supplementation/follow-up not stated in abstract",
    "Only male participants included"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency electromagnetic fields",
    "ELF-EMF",
    "high-voltage electricity lines",
    "occupational exposure",
    "power plant workers",
    "resveratrol",
    "oxidative stress",
    "inflammation",
    "8-OHdG",
    "F2-isoprostane",
    "NF-κB",
    "IL-6"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.95,
      "reason": "Study population is workers with long-term occupational exposure to high-voltage electricity lines (ELF-EMF)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.18632/oncotarget.17668
PubMed: Not supplied

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