Association of Occupational Factors and Dementia or Cognitive Impairment: A Systematic Review and Meta- Analysis

Journal of Alzheimer's disease : JAD · 2020 · Mixed · Low evidence

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MixedLow evidencePaper 2175

Study snapshot

PublicationJournal of Alzheimer's disease : JAD · 2020

Study typemeta_analysis

Reported directionMixed

Evidence ratingLow

Abstract

Association of Occupational Factors and Dementia or Cognitive Impairment: A Systematic Review and Meta- Analysis Liang-Yu Huang, He-Ying Hu, Zuo-Teng Wang, Ya-Hui Ma, Qiang Dong, Lan Tan, Jin-Tai Yu. Association of Occupational Factors and Dementia or Cognitive Impairment: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2020 Sep 19. doi: 10.3233/JAD-200605. Abstract Background: Several existing studies have reported that occupational factors might play an important part in cognitive function with aging. Objective: We aim to explore the associations between modifiable occupational factors and risk of dementia or mild cognitive impairment (MCI). Methods: Adopting random-effect models, this study conducted primary analyses for all occupational factors and subgroup analyses for the effect of occupation type based on prospective cohort and case-control studies searched from PubMed and EMBASE databases up to March 2020. Results: Among the 38,111 identified literatures, 9 studies on occupation type, 4 studies on work complexity, and 30 studies on occupational exposure were included. In terms of occupation type, mental work conferred a 44% reduced risk (95% CI = 0.34-0.94, I² = 85.00%, p < 0.01) for MCI. In terms of work complexity, higher work complexity conferred a 5% reduced risk (95% CI = 0.91-1.00, I² = 57.00%, p < 0.01) for dementia. In terms of occupational exposure, high strain and passive job in the longest-held job conferred a 1.21- and 1.15-fold excess risk (95% CI = 1.05-1.39 I² = 62.00%, p < 0.05; 95% CI = 1.05-1.26 I² = 31.00%, p = 0.23; respectively) of cognitive decline. Besides, magnetic field exposure conferred a 1.26-fold excess risk (95% CI = 1.01-1.57, I² = 69.00%, p < 0.01) for dementia. Conclusion: Novel prevention strategies based on occupational factors may hold promise against dementia and MCI. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typemeta_analysis

Effect directionmixed

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 66% · Peer reviewed: yes

Main findings

This systematic review and meta-analysis (prospective cohort and case-control studies, searched to March 2020) found that magnetic field exposure was associated with an increased risk of dementia (1.26-fold excess risk; 95% CI 1.01–1.57; I²=69%; p<0.01). It also reported associations of job strain/passive job with cognitive decline, and mental work/work complexity with reduced risk of MCI/dementia.

Outcomes measured

dementia
mild cognitive impairment (MCI)
cognitive decline

View raw extracted JSON

{
  "study_type": "meta_analysis",
  "exposure": {
    "band": null,
    "source": "occupational",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "dementia",
    "mild cognitive impairment (MCI)",
    "cognitive decline"
  ],
  "main_findings": "This systematic review and meta-analysis (prospective cohort and case-control studies, searched to March 2020) found that magnetic field exposure was associated with an increased risk of dementia (1.26-fold excess risk; 95% CI 1.01–1.57; I²=69%; p<0.01). It also reported associations of job strain/passive job with cognitive decline, and mental work/work complexity with reduced risk of MCI/dementia.",
  "effect_direction": "mixed",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "systematic review",
    "meta-analysis",
    "occupational exposure",
    "magnetic field exposure",
    "dementia",
    "mild cognitive impairment",
    "cognitive decline",
    "job strain",
    "work complexity",
    "occupation type"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.9,
      "reason": "Includes meta-analyzed evidence on occupational magnetic field exposure and dementia risk."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3233/jad-200605
PubMed: 32986670

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