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Wireless Phone Use and Risk of Adult Glioma: Evidence from Meta-analysis

2018 · Mixed · Low evidence

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MixedLow evidencePaper 2113

This meta-analysis of 10 studies found no statistically significant association between ever use of wireless phones and adult glioma (OR 1.03, 95% CI 0.92–1.16; heterogeneity I2=54.2%). A statistically significant increased risk was reported for long-term use…

Study snapshot

Publicationmanual · 2018
Study typemeta_analysis
Reported directionMixed
Evidence ratingLow

Abstract

Wireless Phone Use and Risk of Adult Glioma: Evidence from Meta-analysis Wang P, Hou C, Li Y, Zhou D. Wireless Phone Use and Risk of Adult Glioma: Evidence from Meta-analysis. World Neurosurgery. Available online 28 April 2018. Objective Wireless phone use has been increasing rapidly and is associated with the risk of glioma. Many studies have been conducted on this association, but did not reach an agreement. The aim of this meta-analysis was to determine the possible association between wireless phone use and the risk of adult glioma. Methods Eligible studies were identified by searching Pubmed and Embase till July 2017. The random- or fixed- effects model was used to combine the results depending on the heterogeneity of the analysis. Publication bias was evaluated using Begg's funnel plot and Egger's regression asymmetry test. Subgroup analysis was performed to evaluate the possible influence of these variables. Results A total of 10 studies about the association of wireless phone use and the risk of glioma were included in this meta-analysis. The combined odd's ratio (OR) of adult glioma associated with ever use of wireless phone was 1.03 (95% CI=0.92-1.16) with high heterogeneity (I2=54.2%, P=0.013). In the subgroup analyses, no significant association was found among tumor location in the temporal lobe and adult glioma risk, with ORs of 1.26 (95% CI=0.87-1.84), 0.93 (95%CI=0.69-1.24), 1.61 (95%CI=0.78-3.33), respectively. Significant association was found in long-term users (≥10 years) with OR 1.33 (95%CI =1.05-1.67) and risk of glioma. Conclusions Our analysis suggested that ever use of wireless phone was not significantly associated with the risk of adult glioma, but could increase the risk in long-term users. sciencedirect.com

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typemeta_analysis
Effect directionmixed
PopulationAdults (adult glioma)
Sample size10
Exposureever use; long-term use (≥10 years)
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

This meta-analysis of 10 studies found no statistically significant association between ever use of wireless phones and adult glioma (OR 1.03, 95% CI 0.92–1.16; heterogeneity I2=54.2%). A statistically significant increased risk was reported for long-term users (≥10 years) (OR 1.33, 95% CI 1.05–1.67).

Outcomes measured

  • Adult glioma risk
  • Glioma risk by tumor location (temporal lobe subgroup)
  • Glioma risk in long-term users (≥10 years)

Limitations

  • High heterogeneity reported for the main analysis (I2=54.2%).
  • Included studies did not reach agreement (as stated by authors).
  • Details of exposure characterization (e.g., frequency, SAR) not provided in abstract.
View raw extracted JSON
{
  "study_type": "meta_analysis",
  "exposure": {
    "band": null,
    "source": "wireless phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "ever use; long-term use (≥10 years)"
  },
  "population": "Adults (adult glioma)",
  "sample_size": 10,
  "outcomes": [
    "Adult glioma risk",
    "Glioma risk by tumor location (temporal lobe subgroup)",
    "Glioma risk in long-term users (≥10 years)"
  ],
  "main_findings": "This meta-analysis of 10 studies found no statistically significant association between ever use of wireless phones and adult glioma (OR 1.03, 95% CI 0.92–1.16; heterogeneity I2=54.2%). A statistically significant increased risk was reported for long-term users (≥10 years) (OR 1.33, 95% CI 1.05–1.67).",
  "effect_direction": "mixed",
  "limitations": [
    "High heterogeneity reported for the main analysis (I2=54.2%).",
    "Included studies did not reach agreement (as stated by authors).",
    "Details of exposure characterization (e.g., frequency, SAR) not provided in abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "wireless phone",
    "mobile phone",
    "glioma",
    "brain tumor",
    "adult",
    "meta-analysis",
    "long-term use",
    "temporal lobe",
    "odds ratio",
    "heterogeneity"
  ],
  "suggested_hubs": [
    {
      "slug": "who-icnirp",
      "weight": 0.35,
      "reason": "Addresses health risk (glioma) from wireless phone use, a topic commonly evaluated in RF exposure health assessments."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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