Gating currents

2018 · Unclear · Insufficient evidence

← Research stream

UnclearInsufficient evidencePaper 2074

This milestone review describes principles of voltage sensing and gating currents in membrane proteins, provides a historical overview of gating current recording, and discusses how gating current recordings inform structural/conformational changes and gating…

Study snapshot

Publicationmanual · 2018

Study typereview

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Gating currents Bezanilla F. Gating currents. J Gen Physiol. 2018 Jun 25. pii: jgp.201812090. doi: 10.1085/jgp.201812090. Abstract Many membrane proteins sense the voltage across the membrane where they are inserted, and their function is affected by voltage changes. The voltage sensor consists of charges or dipoles that move in response to changes in the electric field, and their movement produces an electric current that has been called gating current. In the case of voltage-gated ion channels, the kinetic and steady-state properties of the gating charges provide information of conformational changes between closed states that are not visible when observing ionic currents only. In this Journal of General Physiology Milestone, the basic principles of voltage sensing and gating currents are presented, followed by a historical description of the recording of gating currents. The results of gating current recordings are then discussed in the context of structural changes in voltage-dependent membrane proteins and how these studies have provided new insights on gating mechanisms. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

gating currents
voltage sensing in membrane proteins
conformational changes in voltage-gated ion channels
recording/measurement of gating currents
structural changes in voltage-dependent membrane proteins
gating mechanisms

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "gating currents",
    "voltage sensing in membrane proteins",
    "conformational changes in voltage-gated ion channels",
    "recording/measurement of gating currents",
    "structural changes in voltage-dependent membrane proteins",
    "gating mechanisms"
  ],
  "main_findings": "This milestone review describes principles of voltage sensing and gating currents in membrane proteins, provides a historical overview of gating current recording, and discusses how gating current recordings inform structural/conformational changes and gating mechanisms in voltage-dependent membrane proteins.",
  "effect_direction": "unclear",
  "limitations": [],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "gating current",
    "voltage sensor",
    "electric field",
    "membrane proteins",
    "voltage-gated ion channels",
    "conformational changes",
    "structural changes",
    "gating mechanisms",
    "recording history"
  ],
  "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1085/jgp.201812090
PubMed: Not supplied

Read the original paper →

Related papers

← Back to the Research Library