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Parental Occupational Exposures and Risk of Childhood Acute Leukemia

2018 · No effect · Low evidence

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No effectLow evidencePaper 1945

In this case-control study (108 cases and 108 matched controls), parental occupational exposure (including electromagnetic fields) across four exposure periods was not associated with childhood acute leukemia. High birth weight and family history of cancer we…

Study snapshot

Publicationmanual · 2018
Study typecase_control
Reported directionNo effect
Evidence ratingLow

Abstract

Parental Occupational Exposures and Risk of Childhood Acute Leukemia Kyriakopoulou A, Meimeti E, Moisoglou I, Psarrou A, Provatopoulou X, Dounias G. Parental Occupational Exposures and Risk of Childhood Acute Leukemia. Mater Sociomed. 2018 Oct;30(3):209-214. doi: 10.5455/msm.2018.30.209-214. Abstract INTRODUCTION: Acute leukemia, accounting for 20% of all cancers diagnosed in individuals younger than 19 years old, is the most prevalent childhood malignancy. Among environmental risk factors, parental occupational exposures have attracted scientific interest as potential predisposing factors for childhood leukemia. The role of parental occupational exposure to social contacts, harmful chemicals, electromagnetic fields and ionizing radiation has been investigated with conflicting and inconsistent results. AIM: A case-control study aiming to assess the association between parental occupational exposures to social contacts, chemicals and electromagnetic fields and the risk of offspring acute leukemia. MATERIAL AND METHODS: 108 children with acute leukemia and equal number of matched controls were included. Data on parental occupations before conception, during pregnancy, during breastfeeding and after birth, and on potential risk factors was recorded. Associations between parental exposure and risk of childhood leukemia were estimated. RESULTS: Parental occupational exposure during the four periods of exposure was not associated with childhood leukemia. High birth weight and family history of cancer were associated with the development of childhood acute leukemia. A weak association of maternal medication use during pregnancy and leukemia risk emerged. CONCLUSIONS: Since the causative factors of childhood leukemia remain unknown, further investigation is mandatory for the reduction of disease burden. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typecase_control
Effect directionno_effect
PopulationChildren (cases: acute leukemia) and matched controls; parental occupational exposures assessed
Sample size216
Exposurebefore conception, during pregnancy, during breastfeeding, and after birth
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In this case-control study (108 cases and 108 matched controls), parental occupational exposure (including electromagnetic fields) across four exposure periods was not associated with childhood acute leukemia. High birth weight and family history of cancer were associated with leukemia; a weak association with maternal medication use during pregnancy was reported.

Outcomes measured

  • Childhood acute leukemia risk
  • Associations with high birth weight
  • Associations with family history of cancer
  • Associations with maternal medication use during pregnancy
View raw extracted JSON
{
  "study_type": "case_control",
  "exposure": {
    "band": null,
    "source": "occupational",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "before conception, during pregnancy, during breastfeeding, and after birth"
  },
  "population": "Children (cases: acute leukemia) and matched controls; parental occupational exposures assessed",
  "sample_size": 216,
  "outcomes": [
    "Childhood acute leukemia risk",
    "Associations with high birth weight",
    "Associations with family history of cancer",
    "Associations with maternal medication use during pregnancy"
  ],
  "main_findings": "In this case-control study (108 cases and 108 matched controls), parental occupational exposure (including electromagnetic fields) across four exposure periods was not associated with childhood acute leukemia. High birth weight and family history of cancer were associated with leukemia; a weak association with maternal medication use during pregnancy was reported.",
  "effect_direction": "no_effect",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "childhood acute leukemia",
    "case-control",
    "parental occupational exposure",
    "electromagnetic fields",
    "chemicals",
    "social contacts",
    "pregnancy",
    "breastfeeding"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.9,
      "reason": "Assesses parental occupational exposures including electromagnetic fields in relation to childhood leukemia risk."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.5455/msm.2018.30.209-214
PubMed: Not supplied

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