Transdermal patches loaded with L-cysteine HCL as a strategy for protection from cell phone radiation

2019 · Benefit · Low evidence

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BenefitLow evidencePaper 1904

Study snapshot

Publicationmanual · 2019

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

Transdermal patches loaded with L-cysteine HCL as a strategy for protection from cell phone radiation Omar SM, Nasr M, Rafla DA. Transdermal patches loaded with L-cysteine HCL as a strategy for protection from mobile phone-emitting electromagnetic radiation hazards. Saudi Pharm J. 2019 Jan;27(1):112-125. doi: 10.1016/j.jsps.2018.09.004. Abstract Mobile phone usage has been increased in the last few years emitting electromagnetic radiation (EMR), which disturbs normal cellular processes via oxidative stress. L-cysteine, a glutathione precursor, prevents oxidative damage. Transdermal patches (TDPs) loaded with L-cysteine hydrochloride (L-CyS-HCL) were fabricated by dispersion of L- CyS-HCL 5% w/w and different concentrations of sorbitol as a plasticizer in room-temperature vulcanizable synthetic silicone matrices (RTV-Si). The effect of sorbitol on patch physicochemical parameters was assessed; in-vitro L-CyS-HCL release profiles and ex-vivo permeation were studied. Pharmacokinetic parameters of endogenous synthetized in-vivo glutathione, after receiving IV bolus dose of L-CyS-HCl and L-CyS-HCl-RTV-Si- TDPs were studied in rat model. The influence of L-CyS-HCL-RTV-Si-TDPs against damaging effects of mobile phone EMR on rats' blood and brain tissues was studied. The results revealed that patch plasticity, intensity reflections, surface porosity, L-CyS-HCL release rate and skin permeation increased with increasing sorbitol concentration. Pharmacokinetic profile for IV dose and L-CyS-HCl- RTV-Si-TDPs revealed that the L-CyS-HCl-RTV-Si-TDPs provided a sustained glutathione plasma concentration- time profile over entire patch application. High significant differences in biological parameters (blood and brain samples) were observed for radiated rats using the patch in study compared with positive control rats. Promising long-term strategy for protection against mobile phone hazards was obtained. Open access paper: ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationRats (rat model)

Sample sizeNot supplied

ExposureRF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Increasing sorbitol concentration increased patch plasticity, surface porosity, L-cysteine HCl release rate, and skin permeation. The transdermal patch provided a sustained glutathione plasma concentration–time profile over the application period. Radiated rats using the patch showed highly significant differences in blood and brain biological parameters compared with positive control radiated rats.

Outcomes measured

Patch physicochemical parameters (plasticity, intensity reflections, surface porosity)
In-vitro L-cysteine HCl release
Ex-vivo skin permeation
Pharmacokinetics of endogenous glutathione after IV bolus vs transdermal patch
Blood biological parameters after mobile phone EMR exposure
Brain tissue biological parameters after mobile phone EMR exposure

Limitations

Mobile phone EMR exposure parameters (e.g., frequency, SAR, duration) not specified in the abstract
Sample size not reported in the abstract
Specific biological parameters measured in blood/brain not detailed in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rats (rat model)",
  "sample_size": null,
  "outcomes": [
    "Patch physicochemical parameters (plasticity, intensity reflections, surface porosity)",
    "In-vitro L-cysteine HCl release",
    "Ex-vivo skin permeation",
    "Pharmacokinetics of endogenous glutathione after IV bolus vs transdermal patch",
    "Blood biological parameters after mobile phone EMR exposure",
    "Brain tissue biological parameters after mobile phone EMR exposure"
  ],
  "main_findings": "Increasing sorbitol concentration increased patch plasticity, surface porosity, L-cysteine HCl release rate, and skin permeation. The transdermal patch provided a sustained glutathione plasma concentration–time profile over the application period. Radiated rats using the patch showed highly significant differences in blood and brain biological parameters compared with positive control radiated rats.",
  "effect_direction": "benefit",
  "limitations": [
    "Mobile phone EMR exposure parameters (e.g., frequency, SAR, duration) not specified in the abstract",
    "Sample size not reported in the abstract",
    "Specific biological parameters measured in blood/brain not detailed in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "mobile phone",
    "electromagnetic radiation",
    "RF",
    "oxidative stress",
    "L-cysteine hydrochloride",
    "glutathione",
    "transdermal patch",
    "rat model",
    "brain",
    "blood"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones-rf",
      "weight": 0.9,
      "reason": "Study evaluates effects of mobile phone-emitting electromagnetic radiation and a protective intervention in rats."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.jsps.2018.09.004
PubMed: Not supplied

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