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Weak magnetic fields alter stem cell-mediated growth

2019 · Mixed · Low evidence

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MixedLow evidencePaper 1896

In a planarian regeneration model, static weak magnetic fields (<1 mT) altered stem cell proliferation and subsequent differentiation, associated with changes in ROS accumulation and downstream Hsp70 expression. Depending on field strength, WMF exposure incre…

Study snapshot

Publicationmanual · 2019
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

Weak magnetic fields alter stem cell-mediated growth Van Huizen AV, Morton JM, Kinsey LJ, Von Kannon DG, Saad MA, Birkholz TR, Czajka JM, Cyrus J, Barnes FS, Beane WS. Weak magnetic fields alter stem cell-mediated growth. Science Advances. 5(1). 30 Jan 2019. DOI: 10.1126/sciadv.aau7201. Abstract Biological systems are constantly exposed to electromagnetic fields (EMFs) in the form of natural geomagnetic fields and EMFs emitted from technology. While strong magnetic fields are known to change chemical reaction rates and free radical concentrations, the debate remains about whether static weak magnetic fields (WMFs; <1 mT) also produce biological effects. Using the planarian regeneration model, we show that WMFs altered stem cell proliferation and subsequent differentiation via changes in reactive oxygen species (ROS) accumulation and downstream heat shock protein 70 (Hsp70) expression. These data reveal that on the basis of field strength, WMF exposure can increase or decrease new tissue formation in vivo, suggesting WMFs as a potential therapeutic tool to manipulate mitotic activity. Open access paper: advances.sciencemag.org

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationPlanarian regeneration model (in vivo)
Sample sizeNot supplied
ExposureELF
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In a planarian regeneration model, static weak magnetic fields (<1 mT) altered stem cell proliferation and subsequent differentiation, associated with changes in ROS accumulation and downstream Hsp70 expression. Depending on field strength, WMF exposure increased or decreased new tissue formation in vivo.

Outcomes measured

  • stem cell proliferation
  • stem cell differentiation
  • reactive oxygen species (ROS) accumulation
  • Hsp70 expression
  • new tissue formation/regeneration

Limitations

  • Sample size not reported in the provided abstract/metadata
  • Exposure duration and detailed exposure parameters beyond '<1 mT' not reported in the provided abstract/metadata
  • Findings are from a planarian (non-human) model, limiting direct generalization to humans
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Planarian regeneration model (in vivo)",
  "sample_size": null,
  "outcomes": [
    "stem cell proliferation",
    "stem cell differentiation",
    "reactive oxygen species (ROS) accumulation",
    "Hsp70 expression",
    "new tissue formation/regeneration"
  ],
  "main_findings": "In a planarian regeneration model, static weak magnetic fields (<1 mT) altered stem cell proliferation and subsequent differentiation, associated with changes in ROS accumulation and downstream Hsp70 expression. Depending on field strength, WMF exposure increased or decreased new tissue formation in vivo.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in the provided abstract/metadata",
    "Exposure duration and detailed exposure parameters beyond '<1 mT' not reported in the provided abstract/metadata",
    "Findings are from a planarian (non-human) model, limiting direct generalization to humans"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "weak magnetic fields",
    "static magnetic fields",
    "<1 mT",
    "planarian regeneration",
    "stem cells",
    "proliferation",
    "differentiation",
    "ROS",
    "Hsp70",
    "tissue formation"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1126/sciadv.aau7201
PubMed: Not supplied

Read the original paper →

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