Effects of Exposure to 5.8 GHz EMF on Micronucleus Formation, DNA strand breaks & Heat Shock Protein Expressions in Human Eye Cells

2019 · No effect · Low evidence

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No effectLow evidencePaper 1861

Human corneal epithelial (HCE-T) cells exposed to 5.8-GHz electromagnetic fields at 1 mW/cm2 for 24 h showed no statistically significant increase in micronucleus frequency versus sham-exposed or incubator controls. DNA strand breaks and expression of Hsp27, …

Study snapshot

Publicationmanual · 2019

Study typein_vitro

Reported directionNo effect

Evidence ratingLow

Abstract

Effects of Exposure to 5.8 GHz EMF on Micronucleus Formation, DNA strand breaks & Heat Shock Protein Expressions in Human Eye Cells Miyakoshi J, Tonomura H, Koyama S, Narita E, Shinohara N. Effects of Exposure to 5.8 GHz Electromagnetic Field on Micronucleus Formation, DNA strand breaks, and Heat Shock Protein Expressions in Cells Derived from Human Eye. IEEE Trans Nanobioscience. 2019 Mar 15. doi: 10.1109/TNB.2019.2905491. Abstract In the near future, electrification will be introduced to heavy-duty vehicles and passenger cars. However, wireless power transfer (WPT) requires high energy levels, and the suitability of various types of WPT systems must be assessed. This paper describes a method for solving technical and safety issues associated with this technology. We exposed human corneal epithelial (HCE-T) cells derived from the human eye to 5.8-GHz electromagnetic fields for 24 h. We observed no statistically significant increase in micronucleus (MN) frequency in cells exposed to a 5.8-GHz field at 1 mW/cm2(the general public level in ICNIRP) relative to sham-exposed or incubator controls. Similarly, DNA strand breaks, and expression of heat shock protein (Hsp) Hsp27, Hsp70, and Hsp90α exhibited no statistically significant effects as a result of exposure. These results indicate that exposure to 5.8-GHz electromagnetic fields at 1 mW/cm2 for 24 h has little or no effect on micronucleus formation, DNA strand breaks, and Hsp expression in human eye cells. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionno_effect

PopulationHuman corneal epithelial (HCE-T) cells derived from the human eye

Sample sizeNot supplied

Exposuremicrowave · 5800 MHz · 24 h

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Micronucleus (MN) frequency
DNA strand breaks
Heat shock protein expression (Hsp27, Hsp70, Hsp90α)

Limitations

Sample size not reported in provided abstract/metadata
Only one exposure level reported (1 mW/cm2)
In vitro cell model; generalizability to humans not addressed in provided abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": "wireless power transfer (WPT)",
    "frequency_mhz": 5800,
    "sar_wkg": null,
    "duration": "24 h"
  },
  "population": "Human corneal epithelial (HCE-T) cells derived from the human eye",
  "sample_size": null,
  "outcomes": [
    "Micronucleus (MN) frequency",
    "DNA strand breaks",
    "Heat shock protein expression (Hsp27, Hsp70, Hsp90α)"
  ],
  "main_findings": "Human corneal epithelial (HCE-T) cells exposed to 5.8-GHz electromagnetic fields at 1 mW/cm2 for 24 h showed no statistically significant increase in micronucleus frequency versus sham-exposed or incubator controls. DNA strand breaks and expression of Hsp27, Hsp70, and Hsp90α also showed no statistically significant effects.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Only one exposure level reported (1 mW/cm2)",
    "In vitro cell model; generalizability to humans not addressed in provided abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "5.8 GHz",
    "electromagnetic field",
    "micronucleus",
    "DNA strand breaks",
    "heat shock proteins",
    "Hsp27",
    "Hsp70",
    "Hsp90α",
    "human corneal epithelial cells",
    "HCE-T",
    "wireless power transfer",
    "ICNIRP",
    "1 mW/cm2"
  ],
  "suggested_hubs": [
    {
      "slug": "who-icnirp",
      "weight": 0.62,
      "reason": "Exposure level described as 'general public level in ICNIRP'."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/tnb.2019.2905491
PubMed: Not supplied

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