Radiophysical Microwave Installation for Investigating Biological Effects in Mice with Tumor

2019 · Mixed · Low evidence

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MixedLow evidencePaper 1835

Mice were exposed to 915 MHz microwave radiation at 10 or 100 μW/cm2 for 1 hour daily over 10 days, with mortality recorded for 45 days after tumor transplantation. The authors report that 10 μW/cm2 slowed animal death, while 100 μW/cm2 decreased lifetime; th…

Study snapshot

Publicationmanual · 2019

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Radiophysical Microwave Installation for Investigating Biological Effects in Mice with Tumor Kryukova OV, Pyankov VF, Salomatov YP, Kopylov AF. Radiophysical microwave installation for investigating biological effects in mice with tumor. 2019 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus). 28-31 Jan. 2019. DOI: 10.1109/EIConRus.2019.8657031. Abstract Designing radiophysical devices for investigating the effect of microwave radiation on biological objects is one of the main directions in applied modern radio-electronics. An installation for investigating the radiophysical microwave radiation effects on laboratory animals has been developed, with the frequency being 915 MHz, power of electromagnetic radiation being 10 μW/cm2. The results obtained demonstrate the survival rate of mice with tumor under the influence of electromagnetic field. Excerpts The laboratory animals were exposed to microwave EMR at a frequency of 915 MHz, with the energy flux density being 10 μW / cm2 and 100 μW / cm2.... As a model tumor, Ehrlich ascites carcinoma was used. Ehrlich ascites carcinoma is one of the most common tumors used as a model in scientific research.... After the tumor transplantation the animals were divided into three groups: the control and two experimental ones. (EMR group exposed to 10 μW\cm2 and EMR group exposed to 100μW\cm2). The animals of the experimental groups were daily subjected to electromagnetic radiation for 1 hour during 10 days. The control group was kept under the same conditions without the influence of the electromagnetic radiation. In the course of the experiment the mortality of the animals was recorded during 45 days after the beginning of the tumor transplantation. Thus, independently on the power, the impact of microwave radiation changes the lifetime of the animals with Ehrlich ascites carcinoma. In this case, using the power of 10 μW /cm2 slows down the animal death and the power of 100 μW/cm2 decreases the lifetime of the animals. However, in the group exposed to 100 μW/cm2 no tumor developed after the transplantation. Using the mathematical methods of analysis the author [10], [11] show that there is a connection between the development of cancer diseases among the population and the main factors of the electromagnetic load due to EMR when using MRT as a carcinogenic factor or a factor contributing to cancer genesis. Moreover, some researchers suggest that radiofrequency fields can act as cancer promoters [12]. Thus, it is important to study the impact of electromagnetic microwave radiation on the growth dynamics of tumor cells and their functional condition, for example, in order to estimate the degree of risk of tumor progressing. Consequently, it is necessary to develop a method of estimating the carcinogenic risk under the impact of microwave radiation, in particular to improve the suggested and implemented measures for minimizing unfavorable and harmful effects. It is dangerous to underestimate as well as to overestimate the risk of the impact for the given widely spread factor. ieeexplore.ieee.org

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationMice with transplanted Ehrlich ascites carcinoma (tumor model)

Sample sizeNot supplied

ExposureRF · 915 MHz · 1 hour/day for 10 days

Evidence strengthLowConfidence: 72% · Peer reviewed: unknown

Main findings

Outcomes measured

Survival/mortality (lifetime) over 45 days after tumor transplantation
Tumor development after transplantation

Limitations

Sample size not reported in the provided text
Details of randomization/blinding and statistical analysis are not provided in the provided text
Dosimetry beyond frequency and power density (e.g., SAR) is not reported in the provided text
Outcome reporting is qualitative in the provided text (no numerical survival results provided)

View raw extracted JSON

{
  "publication_year": 2019,
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "radiophysical microwave installation (laboratory exposure)",
    "frequency_mhz": 915,
    "sar_wkg": null,
    "duration": "1 hour/day for 10 days"
  },
  "population": "Mice with transplanted Ehrlich ascites carcinoma (tumor model)",
  "sample_size": null,
  "outcomes": [
    "Survival/mortality (lifetime) over 45 days after tumor transplantation",
    "Tumor development after transplantation"
  ],
  "main_findings": "Mice were exposed to 915 MHz microwave radiation at 10 or 100 μW/cm2 for 1 hour daily over 10 days, with mortality recorded for 45 days after tumor transplantation. The authors report that 10 μW/cm2 slowed animal death, while 100 μW/cm2 decreased lifetime; they also report that in the 100 μW/cm2 group no tumor developed after transplantation.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in the provided text",
    "Details of randomization/blinding and statistical analysis are not provided in the provided text",
    "Dosimetry beyond frequency and power density (e.g., SAR) is not reported in the provided text",
    "Outcome reporting is qualitative in the provided text (no numerical survival results provided)"
  ],
  "evidence_strength": "low",
  "confidence": 0.72,
  "peer_reviewed_likely": "unknown",
  "stance": "neutral",
  "stance_confidence": 0.55,
  "summary": "This conference paper describes a radiophysical microwave exposure installation for studying biological effects in tumor-bearing mice. Mice with Ehrlich ascites carcinoma were exposed to 915 MHz radiation at 10 or 100 μW/cm2 for 1 hour/day for 10 days, and mortality was tracked for 45 days after tumor transplantation. The authors report different effects by power density, including slower death at 10 μW/cm2 and decreased lifetime at 100 μW/cm2, while also stating that no tumor developed in the 100 μW/cm2 group.",
  "key_points": [
    "An experimental microwave exposure setup was developed for laboratory animal studies.",
    "Exposure conditions included 915 MHz at 10 μW/cm2 and 100 μW/cm2.",
    "Mice were exposed 1 hour daily for 10 days following tumor transplantation.",
    "Mortality was recorded for 45 days after the start of tumor transplantation.",
    "The authors report that 10 μW/cm2 slowed death while 100 μW/cm2 decreased lifetime.",
    "The authors also report that no tumor developed after transplantation in the 100 μW/cm2 group."
  ],
  "categories": [
    "Animal Studies",
    "Radiofrequency (RF)",
    "Cancer/Tumor Biology",
    "Exposure Systems & Dosimetry"
  ],
  "tags": [
    "915 MHz",
    "Microwave Radiation",
    "Power Density",
    "Ehrlich Ascites Carcinoma",
    "Tumor-Bearing Mice",
    "Survival",
    "Mortality",
    "Laboratory Exposure System"
  ],
  "keywords": [
    "microwave",
    "915 MHz",
    "electromagnetic radiation",
    "power density",
    "Ehrlich ascites carcinoma",
    "mice",
    "survival rate",
    "mortality"
  ],
  "suggested_hubs": [],
  "social": {
    "tweet": "Conference paper: a 915 MHz microwave exposure setup for tumor-bearing mice (10 or 100 μW/cm², 1 h/day for 10 days) reported power-dependent changes in survival and noted no tumor development in the 100 μW/cm² group.",
    "facebook": "A 2019 conference paper describes a 915 MHz microwave exposure installation for studies in mice with Ehrlich ascites carcinoma. The authors report power-dependent effects on survival (10 vs 100 μW/cm²) and state that no tumor developed in the 100 μW/cm² group.",
    "linkedin": "2019 EIConRus conference paper: development of a 915 MHz microwave exposure installation for tumor-bearing mice (10 or 100 μW/cm²; 1 h/day for 10 days). The authors report power-dependent changes in survival and report no tumor development in the 100 μW/cm² group."
  }
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/eiconrus.2019.8657031
PubMed: Not supplied

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