RF Safe

Effects of 171 MHz Low-Intensity Electromagnetic Field on Glucocorticoid and Mineral Corticoid Activity of the Adrenal Glands of Rats

2019 · Mixed · Low evidence

← Research stream
MixedLow evidencePaper 1690

In rats exposed at 171 MHz CW for 15 days, a biphasic response was reported depending on time and absorbed energy. At low SAR (~0.006 W/kg), exposure was associated with stimulation of adrenal gland activity, with an initial increase in daily corticosterone a…

Study snapshot

Publicationmanual · 2019
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

Effects of 171 MHz Low-Intensity Electromagnetic Field on Glucocorticoid and Mineral Corticoid Activity of the Adrenal Glands of Rats Perov S, Rubtsova N, Balzano Q. Effects of 171 MHz Low-Intensity Electromagnetic Field on Glucocorticoid and Mineral Corticoid Activity of the Adrenal Glands of Rats. Bioelectromagnetics. 2019 Oct 22. doi: 10.1002/bem.22226. Abstract A sub-acute electromagnetic field (EMF) biological effect study was carried out on rats exposed in the Transverse ElectroMagnetic exposure chamber at 171 MHz Continuous Wave (CW). The experiments involved three exposure levels (15, 25, and 35 V/m) for 15 days with triplicate parallel sham-exposed controls in each series. All exposure conditions were simulated for the evaluation of the electromagnetic energy distribution and specific absorption rate (SAR) in the rat phantoms. Studies have shown a biphasic biological response depending on time and absorbed electromagnetic energy. Under low SAR, approximately 0.006 W/kg, EMF exposure leads to the stimulation of adrenal gland activity. This process is accompanied by an initial increase of daily excretion of corticosterone and Na+ , which is seen as a higher Na+ /K+ ratio, followed by a decrease of these parameters over time. It is possible that EMF exposure causes a stress response in animals, which is seen as an increased adrenal activity. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationRats
Sample sizeNot supplied
ExposureRF · 171 MHz · 0.006 W/kg · 15 days; continuous wave (CW); 3 exposure levels (15, 25, 35 V/m)
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In rats exposed at 171 MHz CW for 15 days, a biphasic response was reported depending on time and absorbed energy. At low SAR (~0.006 W/kg), exposure was associated with stimulation of adrenal gland activity, with an initial increase in daily corticosterone and Na+ excretion (higher Na+/K+ ratio) followed by decreases in these parameters over time.

Outcomes measured

  • Adrenal gland activity
  • Daily excretion of corticosterone
  • Daily excretion of Na+
  • Na+/K+ ratio

Limitations

  • Sample size not reported in abstract
  • Outcome measures and methods (e.g., assay details, timing of measurements) not described in abstract
  • Results are summarized without quantitative effect estimates or statistical details in abstract
  • Findings described primarily for low SAR (~0.006 W/kg); effects at other exposure levels not clearly detailed in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 171,
    "sar_wkg": 0.006,
    "duration": "15 days; continuous wave (CW); 3 exposure levels (15, 25, 35 V/m)"
  },
  "population": "Rats",
  "sample_size": null,
  "outcomes": [
    "Adrenal gland activity",
    "Daily excretion of corticosterone",
    "Daily excretion of Na+",
    "Na+/K+ ratio"
  ],
  "main_findings": "In rats exposed at 171 MHz CW for 15 days, a biphasic response was reported depending on time and absorbed energy. At low SAR (~0.006 W/kg), exposure was associated with stimulation of adrenal gland activity, with an initial increase in daily corticosterone and Na+ excretion (higher Na+/K+ ratio) followed by decreases in these parameters over time.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Outcome measures and methods (e.g., assay details, timing of measurements) not described in abstract",
    "Results are summarized without quantitative effect estimates or statistical details in abstract",
    "Findings described primarily for low SAR (~0.006 W/kg); effects at other exposure levels not clearly detailed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "171 MHz",
    "radiofrequency",
    "continuous wave",
    "rats",
    "SAR",
    "adrenal gland",
    "corticosterone",
    "mineralocorticoid activity",
    "Na+/K+ ratio",
    "stress response"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.22226
PubMed: Not supplied

Read the original paper →

Related papers

← Back to the Research Library