Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in

2020 · No effect · Low evidence

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No effectLow evidencePaper 1562

In rats exposed to a 50-Hz electromagnetic field at 500 μT for 24 weeks (20 h/day), heart rate, blood pressure, and pulse rate were not different from sham controls. No significant differences were observed in cardiomyocyte morphology, hypertrophy-related gen…

Study snapshot

Publicationmanual · 2020

Study typeanimal

Reported directionNo effect

Evidence ratingLow

Abstract

Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats Zhang Y, Li L, Liu X , Ding L, Wu X, et al. Examination of the Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats. Front Public Health. 2020 Apr 7;8:87. doi: 10.3389/fpubh.2020.00087. Abstract Background: Whether electromagnetic field (EMF) exposure affects the function of the cardiovascular system is under debate. The present study aimed to investigate the effects of 500 μT EMF exposure on the cardiovascular system in rats. Methods: Forty-eight-week-old male Sprague-Dawley rats were randomly divided into two groups: the sham group and the exposure group. During 24-week EMF exposure (20 h per day), the blood pressure and pulse rate were recorded every 4 weeks. Before sacrifice, electrocardiography, echocardiography, and cardiac catheterization analysis were conducted to evaluate the cardiac function. Meanwhile, hematoxylin-eosin (HE) staining, Western blot, and real-time polymerase chain reaction (PCR) were performed to identify morphological and molecular changes indicative of cardiac remodeling. Results: The heart rate, blood pressure, and pulse rate were not influenced by EMF exposure compared with the control group. In addition, HE staining showed no change in the morphology and arrangement of cardiomyocytes. Further, we found that the mRNA and protein levels of cardiac hypertrophy-related genes were not affected by EMF exposure. Finally, no significant difference was observed in cardiac function between the two groups by echocardiography and cardiac catheterization detection. Conclusion: The 24-week exposure to EMF at 500 μT did not have apparent effects on the cardiovascular system in rats, at least for the variables studied. Open access paper: ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionno_effect

Population48-week-old male Sprague-Dawley rats

Sample sizeNot supplied

ExposureELF · 0.05 MHz · 24 weeks (20 h/day)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

heart rate
blood pressure
pulse rate
electrocardiography (ECG) parameters
echocardiography measures of cardiac function
cardiac catheterization measures of cardiac function
cardiomyocyte morphology/arrangement (HE staining)
mRNA levels of cardiac hypertrophy-related genes
protein levels of cardiac hypertrophy-related genes

Limitations

Sample size not stated in the provided abstract/metadata
Only male rats were studied
Findings limited to the specific exposure level (500 μT), frequency (50 Hz), duration (24 weeks), and measured cardiovascular endpoints

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "24 weeks (20 h/day)"
  },
  "population": "48-week-old male Sprague-Dawley rats",
  "sample_size": null,
  "outcomes": [
    "heart rate",
    "blood pressure",
    "pulse rate",
    "electrocardiography (ECG) parameters",
    "echocardiography measures of cardiac function",
    "cardiac catheterization measures of cardiac function",
    "cardiomyocyte morphology/arrangement (HE staining)",
    "mRNA levels of cardiac hypertrophy-related genes",
    "protein levels of cardiac hypertrophy-related genes"
  ],
  "main_findings": "In rats exposed to a 50-Hz electromagnetic field at 500 μT for 24 weeks (20 h/day), heart rate, blood pressure, and pulse rate were not different from sham controls. No significant differences were observed in cardiomyocyte morphology, hypertrophy-related gene/protein expression, or cardiac function assessed by echocardiography and cardiac catheterization.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not stated in the provided abstract/metadata",
    "Only male rats were studied",
    "Findings limited to the specific exposure level (500 μT), frequency (50 Hz), duration (24 weeks), and measured cardiovascular endpoints"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "50 Hz",
    "ELF EMF",
    "500 μT",
    "rats",
    "cardiovascular system",
    "blood pressure",
    "heart rate",
    "echocardiography",
    "cardiac catheterization",
    "cardiac remodeling",
    "hypertrophy genes"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.35,
      "reason": "Study examines ELF (50 Hz) magnetic field exposure at 500 μT, a level relevant to some occupational settings, though no specific source is stated."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3389/fpubh.2020.00087
PubMed: Not supplied

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