Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions

2020 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 1510

Using 12-h continuous exposures to 6 polychromatic white LED sources at 540 lux, the authors derived a narrow steady-state human Circadian Potency spectral sensitivity curve with a peak at 477 nm and a full-width half-maximum of 438 to 493 nm, based on effect…

Study snapshot

Publicationmanual · 2020

Study typeother

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions Martin Moore-Ede, Anneke Heitmann, Rainer Guttkuhn. J Biological Rhythms. Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions. June 16, 2020. doi.org Abstract Electric light has enabled humans to conquer the night, but light exposure at night can disrupt the circadian timing system and is associated with a diverse range of health disorders. To provide adequate lighting for visual tasks without disrupting the human circadian timing system, a precise definition of circadian spectral sensitivity is required. Prior attempts to define the circadian spectral sensitivity curve have used short (≤90-min) monochromatic light exposures in dark-adapted human subjects or in vitro dark-adapted isolated retina or melanopsin. Several lines of evidence suggest that these dark-adapted circadian spectral sensitivity curves, in addition to 430- to 499-nm (blue) wavelength sensitivity, may include transient 400- to 429-nm (violet) and 500- to 560-nm (green) components mediated by cone- and rod-originated extrinsic inputs to intrinsically photosensitive retinal ganglion cells (ipRGCs), which decay over the first 2 h of extended light exposure. To test the hypothesis that the human circadian spectral sensitivity in light-adapted conditions may have a narrower, predominantly blue, sensitivity, we used 12-h continuous exposures of light-adapted healthy human subjects to 6 polychromatic white light-emitting diode (LED) light sources with diverse spectral power distributions at recommended workplace levels of illumination (540 lux) to determine their effect on the area under curve of the overnight (2000-0800 h) salivary melatonin. We derived a narrow steady-state human Circadian Potency spectral sensitivity curve with a peak at 477 nm and a full-width half-maximum of 438 to 493 nm. This light- adapted Circadian Potency spectral sensitivity permits the development of spectrally engineered LED light sources to minimize circadian disruption and address the health risks of light exposure at night in our 24/7 society, by alternating between daytime circadian stimulatory white light spectra and nocturnal circadian protective white light spectra. journals.sagepub.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionunclear

Populationlight-adapted healthy human subjects

Sample sizeNot supplied

Exposure12-h continuous exposures (overnight 2000–0800 h melatonin assessed)

Evidence strengthInsufficientConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

Area under the curve of overnight (2000–0800 h) salivary melatonin
Derived circadian spectral sensitivity (Circadian Potency) curve parameters (peak wavelength; full-width half-maximum)

Limitations

Sample size not stated in the provided abstract/metadata
Study design details (e.g., randomization, control conditions) not stated
Only workplace illumination level (540 lux) described; other exposure metrics not provided

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "polychromatic white LED light (workplace illumination)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "12-h continuous exposures (overnight 2000–0800 h melatonin assessed)"
  },
  "population": "light-adapted healthy human subjects",
  "sample_size": null,
  "outcomes": [
    "Area under the curve of overnight (2000–0800 h) salivary melatonin",
    "Derived circadian spectral sensitivity (Circadian Potency) curve parameters (peak wavelength; full-width half-maximum)"
  ],
  "main_findings": "Using 12-h continuous exposures to 6 polychromatic white LED sources at 540 lux, the authors derived a narrow steady-state human Circadian Potency spectral sensitivity curve with a peak at 477 nm and a full-width half-maximum of 438 to 493 nm, based on effects on the area under the curve of overnight salivary melatonin.",
  "effect_direction": "unclear",
  "limitations": [
    "Sample size not stated in the provided abstract/metadata",
    "Study design details (e.g., randomization, control conditions) not stated",
    "Only workplace illumination level (540 lux) described; other exposure metrics not provided"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "circadian",
    "LED",
    "polychromatic white light",
    "workplace lighting",
    "melatonin",
    "spectral sensitivity",
    "ipRGC",
    "blue light",
    "circadian disruption"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1177/0748730420923164
PubMed: Not supplied

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