Exposure of 1800 MHz Radiofrequency With SAR 1.6 W/kg Caused a Significant Reduction in CD4+ T Cells and Release of Cytokines In-Vitro

Iranian journal of immunology : IJI · 2020 · Harm · Low evidence

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HarmLow evidencePaper 1492

Study snapshot

PublicationIranian journal of immunology : IJI · 2020

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

Exposure of 1800 MHz Radiofrequency With SAR 1.6 W/kg Caused a Significant Reduction in CD4+ T Cells and Release of Cytokines In-Vitro Maimun Zulhaidah Arthamin, Anis Sulalah, Resvina Resvina, Chomsin Widodo, Agustina Tri Endharti, Edi Widjajanto, Tedy Juliandhy. Exposure of 1800 MHz Radiofrequency With SAR 1.6 W/kg Caused a Significant Reduction in CD4+ T Cells and Release of Cytokines In-Vitro. Iran J Immunol. 2020 Jun;17(2):154-166. doi: 10.22034/iji.2020.84760.1671. Abstract Background: Although there have been many studies investigating the effects of electromagnetic fields on humans cells and tissues, the effects of radiofrequency electromagnetic fields exposure on the cells of the immune system are still controversial. Objective: To investigate the effects of 1800 MHz RF-EMF exposure on peripheral blood mononuclear cells by measuring T helper cells count and the cytokine profile under different conditions of durations and distances. Methods: The peripheral blood mononuclear cells (PBMCs) from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. The effects of RF-EMF exposure on the number of CD4+ T cells, and the expression of IL-2, IL-10, and IL-17a after 48 hours of culture were evaluated using flow cytometry. Results: Our findings indicated that closer distance and longer exposure induced lower number of CD4+ T cells. Similarly the percentages of IL-2, IL-10 and IL-17a expressing CD4+ T cells were decreased significantly. The number of IL-2 expressing CD4+T cells was increased significantly as the duration of exposure was increased, but the number was decreased after 60 minutes exposure when compared with control group with no exposure. Conclusion: Exposure to RF-EMF for 60 minutes at 5 cm distance causes a significant reduction in the number of CD4+ T cells, IL-2, IL-10 and IL-17a expressing T cells. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationPeripheral blood mononuclear cells (PBMCs) from healthy human subjects (in vitro)

Sample sizeNot supplied

ExposureRF · 1800 MHz · 1.6 W/kg · 15, 30, 45, and 60 minutes (distances 5 and 25 cm)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Closer distance and longer exposure were associated with a lower number of CD4+ T cells. Percentages of IL-2, IL-10, and IL-17a expressing CD4+ T cells were reported as significantly decreased; IL-2 expressing CD4+ T cells increased with longer duration but decreased after 60 minutes compared with no-exposure control. The conclusion states that 60 minutes at 5 cm caused significant reductions in CD4+ T cells and IL-2/IL-10/IL-17a expressing T cells.

Outcomes measured

CD4+ T cell count
IL-2 expressing CD4+ T cells
IL-10 expressing CD4+ T cells
IL-17a expressing CD4+ T cells

Limitations

In vitro study (PBMC culture), not direct clinical outcomes
Sample size not reported in abstract
Exposure characterization beyond frequency/SAR/distance/duration not described in abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 1800,
    "sar_wkg": 1.6,
    "duration": "15, 30, 45, and 60 minutes (distances 5 and 25 cm)"
  },
  "population": "Peripheral blood mononuclear cells (PBMCs) from healthy human subjects (in vitro)",
  "sample_size": null,
  "outcomes": [
    "CD4+ T cell count",
    "IL-2 expressing CD4+ T cells",
    "IL-10 expressing CD4+ T cells",
    "IL-17a expressing CD4+ T cells"
  ],
  "main_findings": "Closer distance and longer exposure were associated with a lower number of CD4+ T cells. Percentages of IL-2, IL-10, and IL-17a expressing CD4+ T cells were reported as significantly decreased; IL-2 expressing CD4+ T cells increased with longer duration but decreased after 60 minutes compared with no-exposure control. The conclusion states that 60 minutes at 5 cm caused significant reductions in CD4+ T cells and IL-2/IL-10/IL-17a expressing T cells.",
  "effect_direction": "harm",
  "limitations": [
    "In vitro study (PBMC culture), not direct clinical outcomes",
    "Sample size not reported in abstract",
    "Exposure characterization beyond frequency/SAR/distance/duration not described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "1800 MHz",
    "RF-EMF",
    "SAR 1.6 W/kg",
    "PBMC",
    "CD4+ T cells",
    "cytokines",
    "IL-2",
    "IL-10",
    "IL-17a",
    "flow cytometry",
    "in vitro"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.22034/iji.2020.84760.1671
PubMed: 32602469

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