The influence of prenatal 10 GHz microwave radiation exposure on a developing mice brain

2016 · Harm · Low evidence

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HarmLow evidencePaper 1429

Study snapshot

Publicationmanual · 2016

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

The influence of prenatal 10 GHz microwave radiation exposure on a developing mice brain Sharma A, Kesari KK, Saxena VK, Sisodia R. The influence of prenatal 10 GHz microwave radiation exposure on a developing mice brain.Gen Physiol Biophys. 2016 Oct 27. Abstract Our objective was to investigate alterations in the developing mice brain after intrauterine microwave exposure from different gestation days (0.25 and 11.25) till term. Pregnant mice from 0.25 and 11.25 days of gestation were isolated from an inbred colony and divided into sham-exposed (control) and microwave-exposed (10 GHz) groups. The follow-up study of mice at 3 weeks of age showed significant reduction in the brain and body weight of microwave-exposed group. Results showed an increased level of lipid peroxidation, decreased level of glutathione and protein after microwave exposure on both 0.25 and 11.25 day of gestation. Moreover, changes in cytoarchitechure of hippocampus and cerebellum of the brain and reduction in Purkinje cell number were observed statistically significant after microwave exposure from both 0.25 and 11.25 days of gestation. In conclusion, the degree of severity of damage in neonatal mice brain was much higher, when exposure started from 0.25 day of gestation compared to 11.25 days of gestation. ncbi.nlm.nih.gov Also see: saferemr.com

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationPregnant mice and offspring assessed at 3 weeks of age

Sample sizeNot supplied

Exposuremicrowave · 10000 MHz · Intrauterine exposure from gestation day 0.25 or 11.25 until term

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Offspring from microwave-exposed pregnancies showed reduced brain and body weight at 3 weeks. Microwave exposure was associated with increased lipid peroxidation and decreased glutathione and protein levels, along with statistically significant hippocampal and cerebellar cytoarchitectural changes and reduced Purkinje cell number; effects were reported as more severe when exposure began at gestation day 0.25 versus 11.25.

Outcomes measured

Brain weight
Body weight
Lipid peroxidation
Glutathione level
Protein level
Hippocampus cytoarchitecture
Cerebellum cytoarchitecture
Purkinje cell number

Limitations

Sample size not reported in the provided abstract
Exposure metrics beyond frequency (e.g., SAR/power density) not reported in the provided abstract
Exposure source/setup not described in the provided abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 10000,
    "sar_wkg": null,
    "duration": "Intrauterine exposure from gestation day 0.25 or 11.25 until term"
  },
  "population": "Pregnant mice and offspring assessed at 3 weeks of age",
  "sample_size": null,
  "outcomes": [
    "Brain weight",
    "Body weight",
    "Lipid peroxidation",
    "Glutathione level",
    "Protein level",
    "Hippocampus cytoarchitecture",
    "Cerebellum cytoarchitecture",
    "Purkinje cell number"
  ],
  "main_findings": "Offspring from microwave-exposed pregnancies showed reduced brain and body weight at 3 weeks. Microwave exposure was associated with increased lipid peroxidation and decreased glutathione and protein levels, along with statistically significant hippocampal and cerebellar cytoarchitectural changes and reduced Purkinje cell number; effects were reported as more severe when exposure began at gestation day 0.25 versus 11.25.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the provided abstract",
    "Exposure metrics beyond frequency (e.g., SAR/power density) not reported in the provided abstract",
    "Exposure source/setup not described in the provided abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "prenatal exposure",
    "intrauterine",
    "10 GHz",
    "microwave radiation",
    "mouse",
    "brain development",
    "oxidative stress",
    "lipid peroxidation",
    "glutathione",
    "hippocampus",
    "cerebellum",
    "Purkinje cells"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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