Does cell phone use increase the chances of parotid gland tumor development? A systematic review and meta-analysis

2016 · Harm · Low evidence

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HarmLow evidencePaper 1364

Meta-analysis of three retrospective case-control samples (total 5087 subjects) found cell phone use was associated with higher odds of salivary gland tumor (OR 1.28, 95% CI 1.09–1.51). Authors note results should be interpreted cautiously due to the small nu…

Study snapshot

Publicationmanual · 2016

Study typemeta_analysis

Reported directionHarm

Evidence ratingLow

Abstract

Does cell phone use increase the chances of parotid gland tumor development? A systematic review and meta-analysis de Siqueira EC, de Souza FT, Gomez RS, Gomes CC, de Souza RP. Does cell phone use increase the chances of parotid gland tumor development? A systematic review and meta-analysis. J Oral Pathol Med. 2016 Dec 9. doi: 10.1111/jop.12531. Abstract BACKGROUND: Prior epidemiological studies had examined the association between cell phone use and the development of tumors in the parotid glands. However there is no consensus about the question of whether cell phone use is associated with increased risk of tumors in the parotid glands. We performed a meta-analysis to evaluate the existing literature about the mean question and to determine their statistical significance. METHODS: Primary association studies. Papers that associated cell phone use and parotid gland tumors development were included, with no restrictions regarding publication date, language and place of publication. Systematic literature search using PubMed, Scielo and Embase followed by meta-analysis. RESULTS AND CONCLUSION: Initial screening included 37 articles and three were included in meta-analysis. Using three independent samples including 5087 subjects from retrospective case-control studies, cell phone use seems to be associated with greater odds (1.28, 95%- confidence interval 1.09 - 1.51) to develop salivary gland tumor. Results should be read with caution due to the limited number of studies available and their retrospective design. bit.ly

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typemeta_analysis

Effect directionharm

PopulationNot supplied

Sample size5087

ExposureRF

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

parotid gland tumor
salivary gland tumor

Limitations

Only three studies included in the meta-analysis
Included studies were retrospective case-control designs

View raw extracted JSON

{
  "study_type": "meta_analysis",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": 5087,
  "outcomes": [
    "parotid gland tumor",
    "salivary gland tumor"
  ],
  "main_findings": "Meta-analysis of three retrospective case-control samples (total 5087 subjects) found cell phone use was associated with higher odds of salivary gland tumor (OR 1.28, 95% CI 1.09–1.51). Authors note results should be interpreted cautiously due to the small number of studies and retrospective design.",
  "effect_direction": "harm",
  "limitations": [
    "Only three studies included in the meta-analysis",
    "Included studies were retrospective case-control designs"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "cell phone",
    "mobile phone",
    "parotid gland",
    "salivary gland tumor",
    "case-control",
    "systematic review",
    "meta-analysis"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones-cancer",
      "weight": 0.95,
      "reason": "Assesses association between cell phone use and salivary/parotid gland tumors via systematic review and meta-analysis."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1111/jop.12531
PubMed: Not supplied

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