Effectiveness of Omega-3 Fatty Acid in Protection from Magnetic Field Exposure During Pregnancy: An Experimental Rat Study

2021 · Mixed · Low evidence

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MixedLow evidencePaper 995

Study snapshot

Publicationmanual · 2021

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effectiveness of Omega-3 Fatty Acid in Protection from Magnetic Field Exposure During Pregnancy: An Experimental Rat Study Ugurkan Erkayiran, Tufan Arslanca. Effectiveness of Omega-3 Fatty Acid in Protection from Magnetic Field Exposure During Pregnancy: An Experimental Rat Study. Journal of Reproductive Medicine. Nov 2021. OBJECTIVE: Magnetic fields (MFs) can have several negative effects on the human body. This study aimed to reveal the relationship of adenosine deaminase enzyme (ADA), thyroid-stimulating hormone (TSH), and fetal neural degeneration (FND) with the curative effect of omega-3 fatty acids. STUDY DESIGN: Pregnant Wistar Albino rats (n=30) were separated into 3 groups: Group 1 (sham group), Group 2 (rats exposed to 20 microteslas [μT] for 1 h/day for 10 days), and Group 3 (rats exposed to 20 μT for 4 h/day for 10 days). Blood samples were taken on days 1, 10, and 17 to examine ADA and TSH. Neurodegeneration scores were ana-lyzed with microscopic examination. RESULTS: FND was determined to be greater in the rats exposed to the long-term MFs as compared to short- term MFs (p<0.05). There was a significant difference in terms of ADA and TSH in the rats that received short- and long-term MF as compared to the sham group (p<0.05). The mean scores were higher in the short- and long-term MF groups than in the sham group (p<0.05). ADA activity was found to be higher and TSH was lower in the short- and long-term MF groups (p<0.05). With the use of omega-3, positive alterations in myelin degeneration were observed in the groups exposed to short- and long-term MF (p<0.05). CONCLUSION: While both ADA and TSH increased in both short- and long-term MF exposure, long-term MFs affected FND more than short-term exposure. Although using omega-3 showed a protective effect on the MF- induced FND, it was only protective against short-term exposure. reproductivemedicine.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationPregnant Wistar Albino rats

Sample size30

Exposure1 h/day for 10 days; 4 h/day for 10 days (20 µT magnetic field)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Compared with sham, both short- and long-term magnetic field exposure groups showed significant differences in ADA and TSH (ADA higher; TSH lower) and higher neurodegeneration scores (p<0.05). Fetal neural degeneration was greater with long-term versus short-term exposure (p<0.05). Omega-3 use was associated with positive alterations in myelin degeneration in exposed groups (p<0.05), and was described as protective against MF-induced FND only for short-term exposure.

Outcomes measured

Adenosine deaminase (ADA) activity
Thyroid-stimulating hormone (TSH)
Fetal neural degeneration (FND) / neurodegeneration scores
Myelin degeneration (microscopic assessment)

Limitations

Magnetic field frequency not reported in abstract
Omega-3 dosing/regimen not described in abstract
No details on randomization/blinding or allocation concealment provided in abstract
Outcomes appear limited to biochemical markers and histologic scoring; clinical relevance to humans not established in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "1 h/day for 10 days; 4 h/day for 10 days (20 µT magnetic field)"
  },
  "population": "Pregnant Wistar Albino rats",
  "sample_size": 30,
  "outcomes": [
    "Adenosine deaminase (ADA) activity",
    "Thyroid-stimulating hormone (TSH)",
    "Fetal neural degeneration (FND) / neurodegeneration scores",
    "Myelin degeneration (microscopic assessment)"
  ],
  "main_findings": "Compared with sham, both short- and long-term magnetic field exposure groups showed significant differences in ADA and TSH (ADA higher; TSH lower) and higher neurodegeneration scores (p<0.05). Fetal neural degeneration was greater with long-term versus short-term exposure (p<0.05). Omega-3 use was associated with positive alterations in myelin degeneration in exposed groups (p<0.05), and was described as protective against MF-induced FND only for short-term exposure.",
  "effect_direction": "mixed",
  "limitations": [
    "Magnetic field frequency not reported in abstract",
    "Omega-3 dosing/regimen not described in abstract",
    "No details on randomization/blinding or allocation concealment provided in abstract",
    "Outcomes appear limited to biochemical markers and histologic scoring; clinical relevance to humans not established in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "magnetic field",
    "pregnancy",
    "rat",
    "Wistar Albino",
    "omega-3 fatty acids",
    "adenosine deaminase",
    "thyroid-stimulating hormone",
    "fetal neural degeneration",
    "myelin degeneration"
  ],
  "suggested_hubs": [
    {
      "slug": "pregnancy-and-development",
      "weight": 0.78,
      "reason": "Study examines prenatal exposure and fetal neural degeneration outcomes in pregnant rats."
    },
    {
      "slug": "elF-magnetic-fields",
      "weight": 0.6,
      "reason": "Exposure described as magnetic field intensity (20 µT) with daily durations; frequency not specified."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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