Potential factors affecting chronic chemical intolerance associated with constitutional predisposition or lifestyle and environment during childhood: From a six-year follow-up study

Journal of psychosomatic research · 2021 · Mixed · Low evidence

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MixedLow evidencePaper 933

Study snapshot

PublicationJournal of psychosomatic research · 2021

Study typecohort

Reported directionMixed

Evidence ratingLow

Abstract

Potential factors affecting chronic chemical intolerance associated with constitutional predisposition or lifestyle and environment during childhood: From a six-year follow-up study Kenichi Azuma, Iwao Uchiyama, Naoki Kunugita. Potential factors affecting chronic chemical intolerance associated with constitutional predisposition or lifestyle and environment during childhood: From a six-year follow-up study. J Psychosom Res. 2021 Dec;151:110665. doi: 10.1016/j.jpsychores.2021.110665. Abstract Objective: The Japanese chemical intolerance (JCI) study was conducted in January 2012 with a cohort of 7245 adults from population-based sampling. This study aimed to investigate the childhood constitutional and environmental factors involved in the development of chronic CI from the prospective cohort study. Methods: In the cohort, 4683 persons were identified after six years. Self-reported questionnaires were administered to the subjects to obtain information on CI status; medical history; constitution, lifestyle, and housing environment during childhood; and recent psychosomatic states. We assessed the differences between individuals with persisting CI status during the follow-up (defined as chronic CI) and controls not having CI status during the follow-up. Results: A total of 2500 individuals responded. Multiple logistic regression analyses revealed significant associations between chronic CI and motion sickness to car or bus and allergic conjunctivitis during childhood. Significant associations between a possible increased risk of CI and the existence of high-voltage power lines close to housing, the use of vinyl covering in wall material, the use of strong perfume by a family member, and the experience of stinky odor of paint or wax at elementary school were observed. However, the use of carpet in floor material and plaster coating in wall material was associated with a possible decreased risk of CI. Conclusions: Some potential constitutional predisposition from childhood, including inherent susceptibility in the autonomic nervous system may be involved in the development of CI. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typecohort

Effect directionmixed

PopulationAdults from a population-based sample in Japan (JCI cohort)

Sample size7245

Exposurechildhood exposure/history assessed; 6-year follow-up

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In a 6-year follow-up cohort, multiple logistic regression found significant associations between chronic CI and childhood motion sickness (car/bus) and allergic conjunctivitis. The study also observed significant associations with a possible increased risk of CI for having high-voltage power lines close to housing, vinyl wall covering, strong perfume use by a family member, and experiencing stinky odor of paint or wax at elementary school; carpet flooring and plaster wall coating were associated with a possible decreased risk.

Outcomes measured

chronic chemical intolerance (CI) status (persisting CI during follow-up)

Limitations

CI status and childhood factors were self-reported via questionnaires
Only 2500 of 4683 identified at 6 years responded (potential selection/attrition bias)
Exposure to high-voltage power lines was based on reported proximity; no quantitative EMF measurements reported in abstract

View raw extracted JSON

{
  "study_type": "cohort",
  "exposure": {
    "band": null,
    "source": "high-voltage power lines (proximity)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "childhood exposure/history assessed; 6-year follow-up"
  },
  "population": "Adults from a population-based sample in Japan (JCI cohort)",
  "sample_size": 7245,
  "outcomes": [
    "chronic chemical intolerance (CI) status (persisting CI during follow-up)"
  ],
  "main_findings": "In a 6-year follow-up cohort, multiple logistic regression found significant associations between chronic CI and childhood motion sickness (car/bus) and allergic conjunctivitis. The study also observed significant associations with a possible increased risk of CI for having high-voltage power lines close to housing, vinyl wall covering, strong perfume use by a family member, and experiencing stinky odor of paint or wax at elementary school; carpet flooring and plaster wall coating were associated with a possible decreased risk.",
  "effect_direction": "mixed",
  "limitations": [
    "CI status and childhood factors were self-reported via questionnaires",
    "Only 2500 of 4683 identified at 6 years responded (potential selection/attrition bias)",
    "Exposure to high-voltage power lines was based on reported proximity; no quantitative EMF measurements reported in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "chemical intolerance",
    "chronic CI",
    "prospective cohort",
    "childhood factors",
    "high-voltage power lines",
    "housing environment",
    "perfume",
    "paint odor",
    "motion sickness",
    "allergic conjunctivitis"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.1,
      "reason": "Study concerns environmental/lifestyle factors; not clearly occupational, but includes environmental exposure assessment."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.jpsychores.2021.110665
PubMed: 34763204

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