Chain-Like Structures of Biogenic and Nonbiogenic Magnetic Nanoparticles in Vascular Tissues

Bioelectromagnetics · 2022 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 928

Study snapshot

PublicationBioelectromagnetics · 2022

Study typeother

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Chain-Like Structures of Biogenic and Nonbiogenic Magnetic Nanoparticles in Vascular Tissues Svitlana Gorobets, Oksana Gorobets, Yuri Gorobets, Maryna Bulaievska. Chain-Like Structures of Biogenic and Nonbiogenic Magnetic Nanoparticles in Vascular Tissues. Bioelectromagnetics. 2022 Feb;43(2):119-143. doi: 10.1002/bem.22390. Abstract In this paper, slices of organs from various organisms (animals, plants, fungi) were investigated by using atomic force microscopy and magnetic force microscopy to identify common features of localization of both biogenic and nonbiogenic magnetic nanoparticles. It was revealed that both biogenic and nonbiogenic magnetic nanoparticles are localized in the form of chains of separate nanoparticles or chains of conglomerates of nanoparticles in the walls of the capillaries of animals and the walls of the conducting tissue of plants and fungi. Both biogenic and nonbiogenic magnetic nanoparticles are embedded as a part of the transport system in multicellular organisms. In connection with this, a new idea of the function of biogenic magnetic nanoparticles is discussed, that the chains of biogenic magnetic nanoparticles and chains of conglomerates of biogenic magnetic nanoparticles represent ferrimagnetic organelles of a specific purpose. Besides, magnetic dipole-dipole interaction of biogenic magnetic nanoparticles with magnetically labeled drugs or contrast agents for magnetic resonance imaging should be considered when designing the drug delivery and other medical systems because biogenic magnetic nanoparticles in capillary walls will serve as the trapping centers for the artificial magnetic nanoparticles. The aggregates of both artificial and biogenic magnetic nanoparticles can be formed, contributing to the risk of vascular occlusion. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionunclear

PopulationVarious organisms (animals, plants, fungi); vascular/capillary and conducting tissues examined

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 66% · Peer reviewed: yes

Main findings

Using atomic force microscopy and magnetic force microscopy on organ slices from various organisms, the authors report that both biogenic and nonbiogenic magnetic nanoparticles are localized as chains (of separate nanoparticles or conglomerates) in animal capillary walls and in conducting tissues of plants and fungi. The paper discusses that biogenic magnetic nanoparticle chains may represent ferrimagnetic organelles and notes that interactions with magnetically labeled drugs/contrast agents could lead to aggregation and potentially contribute to vascular occlusion risk.

Outcomes measured

Localization/structure of biogenic and nonbiogenic magnetic nanoparticles in tissues (chain-like structures)
Potential interactions of biogenic magnetic nanoparticles with magnetically labeled drugs/contrast agents (conceptual)
Potential risk of vascular occlusion from aggregates of artificial and biogenic magnetic nanoparticles (conceptual)

Limitations

No EMF exposure parameters (frequency, intensity, SAR, duration) described in abstract
Sample size and selection details not provided in abstract
Several statements are framed as ideas/considerations rather than measured clinical outcomes

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Various organisms (animals, plants, fungi); vascular/capillary and conducting tissues examined",
  "sample_size": null,
  "outcomes": [
    "Localization/structure of biogenic and nonbiogenic magnetic nanoparticles in tissues (chain-like structures)",
    "Potential interactions of biogenic magnetic nanoparticles with magnetically labeled drugs/contrast agents (conceptual)",
    "Potential risk of vascular occlusion from aggregates of artificial and biogenic magnetic nanoparticles (conceptual)"
  ],
  "main_findings": "Using atomic force microscopy and magnetic force microscopy on organ slices from various organisms, the authors report that both biogenic and nonbiogenic magnetic nanoparticles are localized as chains (of separate nanoparticles or conglomerates) in animal capillary walls and in conducting tissues of plants and fungi. The paper discusses that biogenic magnetic nanoparticle chains may represent ferrimagnetic organelles and notes that interactions with magnetically labeled drugs/contrast agents could lead to aggregation and potentially contribute to vascular occlusion risk.",
  "effect_direction": "unclear",
  "limitations": [
    "No EMF exposure parameters (frequency, intensity, SAR, duration) described in abstract",
    "Sample size and selection details not provided in abstract",
    "Several statements are framed as ideas/considerations rather than measured clinical outcomes"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "biogenic magnetic nanoparticles",
    "nonbiogenic magnetic nanoparticles",
    "capillaries",
    "vascular tissues",
    "conducting tissue",
    "atomic force microscopy",
    "magnetic force microscopy",
    "magnetic dipole-dipole interaction",
    "drug delivery",
    "MRI contrast agents",
    "vascular occlusion"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.22390
PubMed: 35077582

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