Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code

2022 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 843

Study snapshot

Publicationmanual · 2022

Study typereview

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code Ricardo Tassinari, Claudia Cavallini, Elena Olivi, Federica Facchin, Valentina Taglioli, Chiara Zannini, Martina Marcuzzi, Carlo Ventura. 2022. Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code. International Journal of Molecular Sciences 23(6):3157. doi: 10.3390/ijms23063157. Abstract We discuss emerging views on the complexity of signals controlling the onset of biological shapes and functions, from the nanoarchitectonics arising from supramolecular interactions, to the cellular/multicellular tissue level, and up to the unfolding of complex anatomy. We highlight the fundamental role of physical forces in cellular decisions, stressing the intriguing similarities in early morphogenesis, tissue regeneration, and oncogenic drift. Compelling evidence is presented, showing that biological patterns are strongly embedded in the vibrational nature of the physical energies that permeate the entire universe. We describe biological dynamics as informational processes at which physics and chemistry converge, with nanomechanical motions, and electromagnetic waves, including light, forming an ensemble of vibrations, acting as a sort of control software for molecular patterning. Biomolecular recognition is approached within the establishment of coherent synchronizations among signaling players, whose physical nature can be equated to oscillators tending to the coherent synchronization of their vibrational modes. Cytoskeletal elements are now emerging as senders and receivers of physical signals, “shaping” biological identity from the cellular to the tissue/organ levels. We finally discuss the perspective of exploiting the diffusive features of physical energies to afford in situ stem/somatic cell reprogramming, and tissue regeneration, without stem cell transplantation. Open access paper: mdpi.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 66% · Peer reviewed: yes

Main findings

The article discusses evidence and concepts suggesting physical forces/energies (including electromagnetic waves and light, alongside nanomechanical motions) contribute to cellular and tissue-level patterning and biological identity, framed as vibrational/informational processes and coherent synchronizations among signaling components. It also discusses a perspective of leveraging diffusive physical energies for in situ cell reprogramming and tissue regeneration without transplantation.

Outcomes measured

cellular decisions/morphogenesis signaling (conceptual)
tissue regeneration (conceptual)
oncogenic drift (conceptual)
molecular patterning/biomolecular recognition (conceptual)
stem/somatic cell reprogramming (conceptual)

Limitations

Narrative/conceptual review; no specific exposure parameters (frequency, intensity/SAR, duration) are provided in the abstract.
No specific study population, sample size, or quantitative effect estimates are described in the abstract.

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "cellular decisions/morphogenesis signaling (conceptual)",
    "tissue regeneration (conceptual)",
    "oncogenic drift (conceptual)",
    "molecular patterning/biomolecular recognition (conceptual)",
    "stem/somatic cell reprogramming (conceptual)"
  ],
  "main_findings": "The article discusses evidence and concepts suggesting physical forces/energies (including electromagnetic waves and light, alongside nanomechanical motions) contribute to cellular and tissue-level patterning and biological identity, framed as vibrational/informational processes and coherent synchronizations among signaling components. It also discusses a perspective of leveraging diffusive physical energies for in situ cell reprogramming and tissue regeneration without transplantation.",
  "effect_direction": "unclear",
  "limitations": [
    "Narrative/conceptual review; no specific exposure parameters (frequency, intensity/SAR, duration) are provided in the abstract.",
    "No specific study population, sample size, or quantitative effect estimates are described in the abstract."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "physical energies",
    "electromagnetic waves",
    "light",
    "vibrations",
    "morphogenesis",
    "tissue regeneration",
    "nanomechanics",
    "cytoskeleton",
    "coherent synchronization",
    "biomolecular recognition",
    "cell reprogramming"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/ijms23063157
PubMed: Not supplied

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