Investigation of Fetuin-A pathway in diabetes mellitus formation in rats exposed to ELF magnetic fields

Electromagnetic biology and medicine · 2022 · Harm · Low evidence

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HarmLow evidencePaper 717

Rats exposed to a 50 Hz ELF magnetic field (0.4 mT) for 6 hours/day for 5 or 10 days showed significant increases in glucose, HbA1c, HbA1c IFCC (p<.001), and Fetuin-A (p<.05) compared with unexposed controls. No significant differences were reported for trans…

Study snapshot

PublicationElectromagnetic biology and medicine · 2022

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Investigation of Fetuin-A pathway in diabetes mellitus formation in rats exposed to ELF magnetic fields Sert C, Delin M, Eren MA, Çakmak Y. Investigation of Fetuin-A pathway in diabetes mellitus formation in rats exposed to elf magnetic fields. Electromagn Biol Med. 2022 Sep 8:1-7. doi: 10.1080/15368378.2022.2117189. Abstract The presence of technological devices in our lives has increased exposure to environmental electromagnetic fields. As a result of this, especially Cancer and Diabetes are increasing.Rats were divided into 3 groups with 12 rats in each group. The 1st experimental group (n = 12) was exposed to a 50 Hz ELF magnetic field of 0.4 mT for 6 hours a day for 5 days, the 2nd experimental group (n = 12) was exposed for 10 days, and the control group (n = 12) was never exposed to a magnetic field. After completing the applications, blood collection from the rats was performed under appropriate conditions, measurements were made in the laboratory, and statistical analysis was performed between the groups. There was no significant difference between the groups in the results of transaminases and lipid profiles and C-Peptide. There was no significant difference in insulin, urea, creatinine, Na, K, Ca, and uric acid parameters between the groups. However, there was a significant increase in glucose, HbA1c, and Hba1 IFCC values between the control group and the experimental groups (p < .001). There was a significant increase in the level of Fetuin-A between the control group and the experimental groups (p < .05). There was an increase in the Fetuin-A, Glucose, HbA1c, and Hba1c IFCC values in both of the experimental groups compared to the control group. We believe that an increase in these values may cause Type 3 diabetes. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationRats

Sample size36

ExposureELF · 6 hours/day for 5 days or 10 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Fetuin-A
glucose
HbA1c
HbA1c IFCC
transaminases
lipid profiles
C-peptide
insulin
urea
creatinine
Na
K
Ca
uric acid

Limitations

Exposure source/context not specified beyond field parameters (50 Hz, 0.4 mT).
Short exposure duration (5 or 10 days) and animal model limits direct applicability to humans.
No details provided in abstract on randomization/blinding or other bias controls.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "6 hours/day for 5 days or 10 days"
  },
  "population": "Rats",
  "sample_size": 36,
  "outcomes": [
    "Fetuin-A",
    "glucose",
    "HbA1c",
    "HbA1c IFCC",
    "transaminases",
    "lipid profiles",
    "C-peptide",
    "insulin",
    "urea",
    "creatinine",
    "Na",
    "K",
    "Ca",
    "uric acid"
  ],
  "main_findings": "Rats exposed to a 50 Hz ELF magnetic field (0.4 mT) for 6 hours/day for 5 or 10 days showed significant increases in glucose, HbA1c, HbA1c IFCC (p<.001), and Fetuin-A (p<.05) compared with unexposed controls. No significant differences were reported for transaminases, lipid profiles, C-peptide, insulin, urea, creatinine, Na, K, Ca, or uric acid.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure source/context not specified beyond field parameters (50 Hz, 0.4 mT).",
    "Short exposure duration (5 or 10 days) and animal model limits direct applicability to humans.",
    "No details provided in abstract on randomization/blinding or other bias controls."
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF magnetic field",
    "50 Hz",
    "0.4 mT",
    "rats",
    "diabetes mellitus",
    "Fetuin-A",
    "glucose",
    "HbA1c"
  ],
  "suggested_hubs": [
    {
      "slug": "elf-emf",
      "weight": 0.9,
      "reason": "Animal study of 50 Hz extremely low frequency magnetic field exposure."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368378.2022.2117189
PubMed: 36073511

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