Status of the Neuroendocrine System in Animals Chronically Exposed to Electromagnetic Fields of 5G Mobile Network Base Stations

Bull Exp Biol Med · 2022 · Harm · Low evidence

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HarmLow evidencePaper 588

Male Wistar rats exposed chronically to multifrequency electromagnetic fields simulating 5G NR/IMT-2020 (250 μW/cm2, 24 h/day for 4 months) showed results suggesting altered functional activity of the hypothalamus-pituitary-adrenal axis and a stress-like effe…

Study snapshot

PublicationBull Exp Biol Med · 2022

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Status of the Neuroendocrine System in Animals Chronically Exposed to Electromagnetic Fields of 5G Mobile Network Base Stations Perov SY, Rubtsova NB, Belaya OV. Status of the Neuroendocrine System in Animals Chronically Exposed to Electromagnetic Fields of 5G Mobile Network Base Stations. Bull Exp Biol Med. 2023 Jan 4. doi: 10.1007/s10517- 023-05689-2. Abstract We studied the biological effect of chronic exposure to multifrequency electromagnetic fields simulating the effects of 5G NR/IMT-2020 mobile communication systems. Male Wistar rats were exposed to 24-h radiation (250 μW/cm2) for 4 months. The exploratory activity of the animals and blood concentrations of ACTH and corticosterone were evaluated at the end of each month of exposure and 1 month after exposure. The results suggest that exposure to multifrequency electromagnetic field simulating the effects of 5G systems affected functional activity of the hypothalamus-pituitary-adrenal axis and was stressful in nature. Excerpts The animals were divided into 5 experimental (exposure to EMF of 5G systems, power density (PD) 250 μW/cm2) and 5 control (sham exposure) groups (12 rats each). Exposure conditions: chronic experiment — exposure for 4 months (120 days; 24-h, 7 days per week) and 1-month (30 days) post exposure period (without irradiation). During exposure period, the animals of experimental groups were kept in radio transparent (plastic) cages. Exposure was carried out by 5G/IMT-2020 base stations with simultaneous use of radio channels with 3.6 GHz (n78 with 100 MHz channel bandwidth), 28 GHz (n257 with 100 MHz channel bandwidth) and 37 GHz (n260 with 400 MHz channel bandwidth) central frequencies.... The neuroendocrine system of rats responded to chronic 4-month EMF exposure by waveform changes of serum levels of ACTH and corticosterone. ACTH content had a tendency to increase after 3 months of the experiment (Fig. 1). Changes in serum corticosterone content in exposed animals were more pronounced; significant differences from the control group were revealed after 1 and 2 months of exposure and the maximum increase was found 1 month after end of exposure (Fig. 2). Chronic exposure induced changes in orientation and exploratory activity and emotional state of experimental animals. These changes were detected starting from 3rd month of exposure, but did not reach significance threshold, and 1 month after the end of irradiation, the excitation and inhibition processes in the CNS returned to normal. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationMale Wistar rats

Sample sizeNot supplied

Exposure24-h radiation for 4 months (with follow-up 1 month after exposure)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Exploratory activity
Blood ACTH concentration
Blood corticosterone concentration
Hypothalamus-pituitary-adrenal (HPA) axis functional activity/stress response

Limitations

Sample size not reported in the abstract
Frequencies and other exposure characterization details (beyond multifrequency and power density) not reported
Results described as suggestive; quantitative results not provided in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "5G mobile network base stations (simulated 5G NR/IMT-2020)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "24-h radiation for 4 months (with follow-up 1 month after exposure)"
  },
  "population": "Male Wistar rats",
  "sample_size": null,
  "outcomes": [
    "Exploratory activity",
    "Blood ACTH concentration",
    "Blood corticosterone concentration",
    "Hypothalamus-pituitary-adrenal (HPA) axis functional activity/stress response"
  ],
  "main_findings": "Male Wistar rats exposed chronically to multifrequency electromagnetic fields simulating 5G NR/IMT-2020 (250 μW/cm2, 24 h/day for 4 months) showed results suggesting altered functional activity of the hypothalamus-pituitary-adrenal axis and a stress-like effect.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the abstract",
    "Frequencies and other exposure characterization details (beyond multifrequency and power density) not reported",
    "Results described as suggestive; quantitative results not provided in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "5G",
    "NR",
    "IMT-2020",
    "multifrequency electromagnetic fields",
    "base station simulation",
    "chronic exposure",
    "rats",
    "ACTH",
    "corticosterone",
    "HPA axis",
    "stress",
    "exploratory activity"
  ],
  "suggested_hubs": [
    {
      "slug": "5g-policy",
      "weight": 0.62,
      "reason": "Study simulates multifrequency EMF effects of 5G NR/IMT-2020 base stations and assesses biological effects."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/s10517
PubMed: 36598666

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