Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation

Brain sciences · 2023 · Mixed · Low evidence

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MixedLow evidencePaper 427

Study snapshot

PublicationBrain sciences · 2023

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation Wang H, Zhao H, Li C, Dong J, Zhao J, Yue H, Lai Y, Zhao L, Wang H, Zhang J, Xu X, Yao B, Zhou H, Nie B, Du X, Peng R. Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation. Brain Sci. 2023 Jun 28;13(7):1006. doi: 10.3390/brainsci13071006. Abstract Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm2 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) (p = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) (p = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm2 1.5 GHz MW radiation, a significantly decreased γ (p = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationRats

Sample sizeNot supplied

Exposuremicrowave · 1500 MHz · acute

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Compared with sham, rats exposed to 30 mW/cm2 1.5 GHz microwave radiation showed decreased normalized clustering coefficient (γ) 1 day after exposure and prolonged average escape latency 3 days after exposure. After 10 mW/cm2 1.5 GHz, γ decreased without changes in average escape latency. No adverse effects on average escape latency or topological parameters were observed after 9.375 GHz microwave radiation.

Outcomes measured

Spatial memory performance (Morris water maze; average escape latency)
Resting-state fMRI brain network topology (normalized clustering coefficient γ and other topological parameters)

Limitations

Sample size not stated in provided abstract
Exposure duration details beyond 'acute' not provided
SAR not reported (only power density reported)
Details of randomization/blinding and other methodological controls not provided in abstract

View raw extracted JSON

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  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 1500,
    "sar_wkg": null,
    "duration": "acute"
  },
  "population": "Rats",
  "sample_size": null,
  "outcomes": [
    "Spatial memory performance (Morris water maze; average escape latency)",
    "Resting-state fMRI brain network topology (normalized clustering coefficient γ and other topological parameters)"
  ],
  "main_findings": "Compared with sham, rats exposed to 30 mW/cm2 1.5 GHz microwave radiation showed decreased normalized clustering coefficient (γ) 1 day after exposure and prolonged average escape latency 3 days after exposure. After 10 mW/cm2 1.5 GHz, γ decreased without changes in average escape latency. No adverse effects on average escape latency or topological parameters were observed after 9.375 GHz microwave radiation.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not stated in provided abstract",
    "Exposure duration details beyond 'acute' not provided",
    "SAR not reported (only power density reported)",
    "Details of randomization/blinding and other methodological controls not provided in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "1.5 GHz",
    "9.375 GHz",
    "power density",
    "rats",
    "spatial memory",
    "Morris water maze",
    "resting-state fMRI",
    "brain network",
    "topological organization",
    "normalized clustering coefficient"
  ],
  "suggested_hubs": [
    {
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      "weight": 0.9,
      "reason": "Rat experiment assessing behavioral and brain network outcomes after acute microwave exposure."
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}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/brainsci13071006
PubMed: 37508937

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