RF Safe

0.263 terahertz irradiation induced genes expression changes in Caenorhabditis elegans (roundworm)

iScience · 2024 · Harm · Low evidence

← Research stream
HarmLow evidencePaper 220

Whole-body exposure to 0.263 THz irradiation in C. elegans was associated with epidermal ultrastructure damage, inhibited expression of cuticle collagen genes, and impaired movement under high-power irradiation. Genes involved in immune and neural systems wer…

Study snapshot

PublicationiScience · 2024
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

0.263 terahertz irradiation induced genes expression changes in Caenorhabditis elegans (roundworm) Shang S, Gao F, Zhang Q, Song T, Wang W, Liu D, Gong Y, Lu X. 0.263 terahertz irradiation induced genes expression changes in Caenorhabditis elegans. iScience. 2024 Mar 2;27(4):109391. doi: 10.1016/j.isci.2024.109391. Abstract The biosafety of terahertz (THz) waves has emerged as a new area of concern with the gradual application of terahertz radiation. Even though many studies have been conducted to investigate the influence of THz radiation on living organisms, the biological effects of terahertz waves have not yet been fully revealed. In this study, Caenorhabditis elegans (C. elegans) was used to evaluate the biological consequences of whole-body exposure to 0.263 THz irradiation. The integration of transcriptome sequencing and behavioral tests of C. elegans revealed that high-power THz irradiation damaged the epidermal ultrastructures, inhibited the expression of the cuticle collagen genes, and impaired the movement of C. elegans. Moreover, the genes involved in the immune system and the neural system were dramatically down-regulated by high-power THz irradiation. Our findings offer fresh perspectives on the biological impacts of high-power THz radiation that could cause epidermal damage and provoke a systemic response. Open access paper: cell.com

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationCaenorhabditis elegans (C. elegans)
Sample sizeNot supplied
ExposureTHz · 263000 MHz
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Whole-body exposure to 0.263 THz irradiation in C. elegans was associated with epidermal ultrastructure damage, inhibited expression of cuticle collagen genes, and impaired movement under high-power irradiation. Genes involved in immune and neural systems were reported as dramatically down-regulated by high-power THz irradiation.

Outcomes measured

  • Gene expression changes (transcriptome sequencing)
  • Behavior/movement impairment
  • Epidermal ultrastructure damage
  • Cuticle collagen gene expression
  • Immune system gene expression
  • Neural system gene expression

Limitations

  • Exposure duration not stated in abstract
  • Specific exposure metrics (e.g., power density, SAR) not provided in abstract
  • Sample size not provided in abstract
  • Findings described for 'high-power' irradiation; effects at lower power not described in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "THz",
    "source": null,
    "frequency_mhz": 263000,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Caenorhabditis elegans (C. elegans)",
  "sample_size": null,
  "outcomes": [
    "Gene expression changes (transcriptome sequencing)",
    "Behavior/movement impairment",
    "Epidermal ultrastructure damage",
    "Cuticle collagen gene expression",
    "Immune system gene expression",
    "Neural system gene expression"
  ],
  "main_findings": "Whole-body exposure to 0.263 THz irradiation in C. elegans was associated with epidermal ultrastructure damage, inhibited expression of cuticle collagen genes, and impaired movement under high-power irradiation. Genes involved in immune and neural systems were reported as dramatically down-regulated by high-power THz irradiation.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure duration not stated in abstract",
    "Specific exposure metrics (e.g., power density, SAR) not provided in abstract",
    "Sample size not provided in abstract",
    "Findings described for 'high-power' irradiation; effects at lower power not described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "terahertz",
    "THz",
    "0.263 THz",
    "Caenorhabditis elegans",
    "whole-body exposure",
    "transcriptome sequencing",
    "gene expression",
    "epidermis",
    "cuticle collagen",
    "movement",
    "immune system",
    "neural system"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.isci.2024.109391
PubMed: Not supplied

Read the original paper →

Related papers

← Back to the Research Library